@misc{10481/87182,
year = {2015},
url = {https://hdl.handle.net/10481/87182},
abstract = {Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease
and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the
beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver
alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old)
followed a protocol of AIT (4 min at 65%–80% of maximal oxygen uptake, followed by 3 min at 50%–65% of maximal oxygen
uptake for 45–60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats
had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the
curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced
the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPAR , as well
as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT
protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.},
organization = {Junta de Andalucía  P09- AGR-4658},
organization = {Institute for Health and Wellbeing Research},
organization = {Ministry of Economy and Competitiveness (MINECO, Spain)},
organization = {European Union AGL2013-43247-R},
organization = {FEDER program},
publisher = {Canadian Science Publishing},
title = {Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats},
doi = {DOI: 10.1139/apnm-2015-0141},
author = {Kapravelou, Garyfallia and Martínez Martínez, Rosario and Andrade, Ana and Nebot Valenzuela, Elena and Camiletti-Moirón, Daniel and Aparicio García-Molina, Virginia and López-Jurado Romero De La Cruz, María and Aranda Ramírez, Pilar and Arrebola Vargas, Francisco Jesús and Fernández Segura, Eduardo and Bermano, Giovanna and Goua, Marie and Galisteo Moya, Milagros and Porres Foulquie, Jesús María},
}