@misc{10481/86333,
year = {2016},
month = {4},
url = {https://hdl.handle.net/10481/86333},
abstract = {The aim of this study was to review different animal models of Central Diabetes Insipidus, a neuro-
biological syndrome characterized by the excretion of copious amounts of diluted urine (polyuria), a
consequent water intake (polydipsia), and a rise in the serum sodium concentration (hypernatremia).
In rodents, Central Diabetes Insipidus can be caused by genetic disorders (Brattleboro rats) but also by
various traumatic/surgical interventions, including neurohypophysectomy, pituitary stalk compression,
hypophysectomy, and median eminence lesions. Regardless of its etiology, Central Diabetes Insipidus
affects the neuroendocrine system that secretes arginine vasopressin, a neurohormone responsible for
antidiuretic functions that acts trough the renal system. However, most Central Diabetes Insipidus mod-
els also show disorders in other neurobiological systems, specifically in the secretion of oxytocin, a
neurohormone involved in body sodium excretion.
Although the hydromineral behaviors shown by the different Central Diabetes Insipidus models have
usually been considered as very similar, the present review highlights relevant differences with respect
to these behaviors as a function of the individual neurobiological systems affected. Increased understand-
ing of the relationship between the neuroendocrine systems involved and the associated hydromineral
behaviors may allow appropriate action to be taken to correct these behavioral neuroendocrine deficits.},
organization = {Department of Psychobiology and Mind, Brain and Behavior Research Center, (CIMCYC), University of Granada, Granada 18071, Spain},
organization = {University of Granada
and Spanish Ministry of Education and Culture (national R + D Plan
PSI2010-17400)},
publisher = {Elsevier},
keywords = {Brattleboro rat},
keywords = {Hereditary and traumatic diabetes insipidus},
keywords = {Arginine vasopressin},
keywords = {Oxytocin},
keywords = {Water intake},
keywords = {Urine volume},
keywords = {Natriuresis},
keywords = {Polydipsia},
keywords = {Synergic hormonal effects},
title = {Animal models of Central Diabetes Insipidus: Human relevance of acquired beyond hereditary syndromes and the role of oxytocin},
doi = {http://dx.doi.org/10.1016/j.neubiorev.2016.02.023},
author = {Bernal Benítez, Antonio and Mahía Rodríguez, Javier and Puerto Salgado, Amadeo},
}