@misc{10481/85931,
year = {2023},
month = {9},
url = {https://hdl.handle.net/10481/85931},
abstract = {Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack of investment in research, despite the fact that almost one million new cases are reported every year. Four 7-oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine (HftpO) first-row transition complexes (Cu, Co, Ni, Zn) have been studied for the first time in vitro against five different species of Leishmania spp. (L. infantum, L. braziliensis, L. donovani, L. peruviana and L. mexicana) as well as Trypanosoma cruzi, showing higher efficacy than the reference commercial drugs. UV and luminescence properties were also evaluated. As a proof of concept, anchoring of a model high-effective-metal complex as an antiparasitic agent on silica nanoparticles was carried out for the first time, and drug-release behaviour was evaluated, assessing this new approach for drug vehiculation.},
organization = {MCIN/AEI/10.13039/501100011033/  RTI2018-094322-B-I00, RED2022-134091-T},
organization = {ERDF A way of making Europe},
organization = {European Union},
organization = {Junta de Andalucía},
publisher = {MDPI},
keywords = {Metal complex},
keywords = {Coordination chemistry},
keywords = {Leishmaniasis},
keywords = {Antiparasitic activity},
keywords = {Drug release},
keywords = {Nanoparticles},
title = {First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies},
doi = {10.3390/ph16101380},
author = {Martín Montes, Álvaro Miguel and Jiménez-Falcao, Sandra and Gómez-Ruiz, Santiago and Marín Sánchez, Clotilde and Méndez Arriaga, José Manuel},
}