@misc{10481/85903,
year = {2023},
month = {10},
url = {https://hdl.handle.net/10481/85903},
abstract = {Background: As exercise exerts neurobiological and immunomodulatory effects, it might also act as a
disease-modifying intervention in MS. However, a clear mechanistic link between exercise and diseasemodifying
effects in MS has yet to be established.
Objective: Establish recommendations for future mechanistic exercise studies in MS.
Methods: In regular meetings, members of the mechanisms of action group within the MoXFo (Moving
eXercise research Forward in MS) initiative evaluated gaps of knowledge and discussed unmet needs in
mechanistic MS research.
Results: We concluded that biomarkers assessed in translational studies in humans and animals are essential
to decipher the underlying mechanisms of exercise in MS. Consequently, we defined clear definitions
of different types of biomarkers examined in MS exercise studies and operationalized their use to align
with the research question and optimal testing time points. Furthermore, we provide key considerations to
improve the rigor of translational studies and defined minimal reporting criteria for animal studies.
Conclusion: The resulting recommendations are intended to improve the quality of future mechanistic
exercise studies in MS and consequently lead to a better understanding of therapeutic approaches.},
organization = {Advanced
Clinician-Scientist Fellowship from the BMBF (iSTAR,
01EO2106)},
organization = {Hertie Network of Excellence in
Clinical Neuroscience of the Gemeinnützige Hertie-
Stiftung},
organization = {University Medical Center Hamburg-Eppendorf,
Deutsche Forschungsgemeinschaft (SFB1328,
SPP1738, KFO296, FOR2289, FOR2879, FOR5068,
and FR1720/11-2)},
organization = {Gemeinnützige Hertie-Stiftung,
Deutsche Multiple Sklerose Gesellschaft (DMSG;
V6.2)},
organization = {Bundesministerium für Bildung und
Forschung (Target validation, 16GW0308K)},
publisher = {SAGE},
keywords = {Multiple sclerosis},
keywords = {Biomarkers},
keywords = {Exercise},
keywords = {Mechanism},
title = {The MoxFo initiative—Mechanisms of action: Biomarkers in multiple sclerosis exercise studies},
doi = {10.1177/13524585231204453},
author = {Rosenkranz, Sina C. and Erickson, Kirk I. and MoXFo initiative},
}