@misc{10481/85611,
year = {2023},
month = {10},
url = {https://hdl.handle.net/10481/85611},
abstract = {We aimed to investigate the effect of three types of exercise interventions
on memory (i.e., immediate memory (IM), long-term
memory (LTM), and
recognition). We also investigated whether exercise-induced
changes in circulating
S-Klotho
and 1,25-dihydroxivitamin
D (1,25(OH)2D) levels were related to
those observed in memory in healthy middle-aged
sedentary adults. A 12-week
randomized controlled trial was performed with a parallel-group
design. Seventy-four
participants (45–65
years old: 53% women) were randomly assigned to (1)
no exercise (control) group, (2) concurrent training based on the international
physical activity recommendations (PAR) group, (3) high-intensity
interval
training (HIIT) group, or (4) HIIT plus whole-body
electromyostimulation (HIIT-EMS)
group. Memory outcomes were assessed using the Wechsler Memory Scale-third
edition. S-Klotho
plasma levels were determined according to a solid-phase
sandwich enzyme-linked
immunosorbent assay kit while 1,25(OH)2D plasma
levels were measured using a DiaSorin-Liaison
immunochemiluminometric
analyzer. IM-Verbal
Paired Associates (IM-VPA)
and IM-Logical
Memory (IM-LM)
were improved in both the HIIT and HIIT-EMS
groups compared with the
control group (all p ≤ 0.045). Exercise-induced
changes in S-Klotho
plasma levels
were positively associated with those observed in IM, LTM, and recognition (all
p ≤ 0.007), whereas exercise-induced
changes in 1,25(OH)2D plasma levels were
directly related to changes in IM and LTM (all p ≤ 0.048). In conclusion, a 12-week
HIIT intervention with or without WB-EMS
seems to be the most effective
exercise program to improve IM. The significant and positive associations between
exercise-induced
changes in S-Klotho
and 1,25(OH)2D levels with those observed
in memory outcomes suggest that these factors may be potentially related to
exercise-induced
improvements of memory in middle-aged
adults.},
organization = {FEDER/Junta de Andalucía-Consejería
de Economía y Conocimiento/Proyecto
B462,},
organization = {Grant/Award Number: CTS-363-
UGR18},
organization = {Spanish Ministry of Education},
organization = {Grant/Award Number: FPU18/03655},
publisher = {Wiley},
keywords = {1,25-dihydroxivitamin D},
keywords = {Long-term memory},
keywords = {Physical exercise},
keywords = {Short-term memory},
keywords = {S-Klotho},
title = {Physical exercise improves memory in sedentary middle-aged adults: Are these exercise-induced benefits associated with S-Klotho and 1,25-dihydroxivitamin D? The FIT-AGEING randomized controlled trial},
doi = {10.1111/sms.14519},
author = {Vázquez Lorente, Héctor and De-la-O, Alejandro and Amaro Gahete, Francisco José},
}