@misc{10481/85579,
year = {2023},
month = {10},
url = {https://hdl.handle.net/10481/85579},
abstract = {Objective: This study aimed to (1) characterize cardiometabolic factors in self-reported hip
and knee osteoarthritis (OAD) across four body composition phenotypes defined by muscle mass
and adiposity, and (2) associate risk factors with diabetes and hypertension (HTN). Methods: A crosssectional
analysis of the Chilean National Health Survey 2016–17 (n = 4996) stratified participants
into four groups: low skeletal muscle mass/high waist circumference (Low-SMM/High-WC), low
SMM/low WC (Low-SMM/Low-WC), high SMM/high WC (High-SMM/High-WC), and high
SMM/low WC (reference group). Each group was further divided into subgroups with or without
diagnosed hip or knee OAD. The main outcomes were fasting plasma glucose, systolic (SBP)/diastolic
(DBP) blood pressure (continuous outcomes), and other secondary factors such as cardiovascular risk
(CVR). Results: In the hip OAD subgroup, the Low-SMM/High-WC groups had significantly higher
SBP versus the reference value (145 vs. 127 mmHg, p < 0.0001, diff +18 mmHg). In the knee OAD
subgroup, the Low-SMM/High-WC groups had significantly higher SBP versus the reference value
(141 vs. 134 mmHg, p < 0.0001, diff +7 mmHg). The SBP showed a significant interaction between the
group and OAD diagnosis (p = 0.007 hip OAD; p < 0.0001 knee OAD). Conclusions: Hip and knee
OAD associates with elevated SBP/DBP in older adults. OAD groups showed an OR above 2 for
diabetes, 2.7 for HTN, 4.5 for metabolic syndrome, and over 2 for moderate-to-high cardiovascular
risk. OAD interacts substantially with cardiometabolic factors, especially in low muscle mass/high
adiposity phenotypes. Lifestyle optimization of physical activity and nutrition to preserve muscle
mass and mitigate adiposity is essential for cardiometabolic health promotion in OAD patients},
publisher = {MDPI},
keywords = {Osteoarthritis},
keywords = {Diabetes},
keywords = {Arterial hypertension},
keywords = {Older adults},
keywords = {Skeletal muscle mass},
keywords = {Body fat},
title = {A Higher Skeletal Muscle Mass and Lower Adiposity Phenotype Is Associated with Better Cardiometabolic Control in Adults with Hip and Knee Osteoarthritis: Results from the Chilean National Health Survey 2016–2017},
doi = {10.3390/nu15194263},
author = {Guede Rojas, Francisco Alfonso and Delgado Floody, Pedro},
}