@misc{10481/85440,
year = {2023},
month = {10},
url = {https://hdl.handle.net/10481/85440},
abstract = {Argan tree is mainly used to obtain the oil from its seeds in a process that generates by-products such as the pulp
of the fruit. The aim of this study was to assess the in vitro antioxidant activity and profile of bioactive compounds
from an argan fruit extract, and to assay the metabolic effects of the argan pulp intake in a mouse experimental
model. Our results showed a high in vitro antioxidant activity in ethanolic extracts of argan juice and pulp
measured as total polyphenol content, reducing capacity, ABTS, DPPH, and lipid peroxidation inhibition capacity.
In addition, several bioactive compounds with antioxidant, hypoglycemic, and anti-inflammatory activity
were identified (vaccihein A, bergapten, methyl chloragenate, 2-O-caffeoyl glucaric acid, avicularin, quercetin-3-
O-sophoroside, prodelphinidin B4 and mirificin). Dietary intake of argan pulp induced a remarkable hypoglycemic
activity and decreased the gene expression of inflammatory markers. Gene expression and enzyme activity
of liver antioxidant and detoxifying enzymes were differentially affected by argan pulp intake, whereas gut
microbiota was modulated decreasing the Firmicutes/Bacteroidetes ratio. In conclusion, argan pulp can be
considered a functional food or ingredient with beneficial effects on several metabolism biomarkers.},
organization = {University of Granada, Junta de
Andalucía, Spanish Ministry of Science, Innovation, and Universities},
organization = {European Union through projects PTQ-17-09172},
organization = {RTI2018-
100934-B-I00},
organization = {RTC2019-006870-1},
organization = {B-AGR-662-UGR20},
organization = {FEDER
program},
organization = {AGR145},
organization = {CTS164},
organization = {CTS107 (Andalusian Government)},
publisher = {Elsevier},
keywords = {Argan pulp},
keywords = {Functional ingredient},
keywords = {Polyphenols},
keywords = {Insulin resistance},
keywords = {Gut microbiota},
keywords = {Antioxidant activity},
title = {Argan pulp as a novel functional ingredient with beneficial effects on multiple metabolism biomarkers},
doi = {10.1016/j.jff.2023.105864},
author = {Martínez Martínez, Rosario and Ortuño Guzmán, Ana María and Kapravelou, Garyfallia and Melguizo Alonso, Consolación and Prados Salazar, José Carlos and López-Jurado Romero De La Cruz, María and Porres Foulquie, Jesús María},
}