@misc{10481/85292,
year = {2023},
month = {9},
url = {https://hdl.handle.net/10481/85292},
abstract = {Tissue engineering is a relatively recent research area aimed at developing artificial tissues that can restore, maintain, or even improve the anatomical and/or functional integrity of injured tissues. Otolaryngology, as a leading surgical specialty in head and neck surgery, is a candidate for the use of these advanced therapies and medicinal products developed. Nevertheless, a knowledge-based analysis of both areas together is still needed. The dataset was retrieved from the Web of Science database from 1900 to 2020. SciMAT software was used to perform the science mapping analysis and the data for the biomedical translation identification was obtained from the iCite platform. Regarding the analysis of the cognitive structure, we find consolidated research lines, such as the generation of cartilage for use as a graft in reconstructive surgery, reconstruction of microtia, or the closure of perforations of the tympanic membrane. This last research area occupies the most relevant clinical translation with the rest of the areas presenting a lower translational level. In conclusion, Tissue engineering is still in an early translational stage in otolaryngology, otology being the field where most advances have been achieved. Therefore, although otolaryngologists should play an active role in translational research in tissue engineering, greater multidisciplinary efforts are required to promote and encourage the translation of potential clinical applications of tissue engineering for routine clinical use},
organization = {Universidad Peruana
de Ciencias Aplicadas, Lima, Perú (UPC-ExPost-2023-2)},
organization = {The
PECART-0027-2020 (Consejería de Salud y Familias, Junta
de Andalucía, Spain)},
organization = {ProyExcel_00875 (Consejería
de Transformación Económica, Industria, Conocimiento y
Universidades, Junta de Andalucía, Spain)},
organization = {Research Group
#CTS-1028 (MP-M and PG-M, Junta de Andalucía, Spain)},
publisher = {Oxford University Press},
keywords = {Cellular therapy},
keywords = {Extracellular vesicles},
keywords = {Oral mesenchymal stem cells},
keywords = {Bone regeneration},
keywords = {Preclinical models},
keywords = {Angiogenesis},
keywords = {Osteogenesis},
keywords = {Proinflammatory cytokines},
title = {Preclinical Evidence for the Use of Oral Mesenchymal Stem Cell-Derived Extracellular Vesicles in Bone Regenerative Therapy: A Systematic Review},
doi = {10.1093/stcltm/szad059},
author = {Olaechea, Allinson and Benabdellah, Karim and Padial Molina, Miguel and Galindo Moreno, Pablo Antonio},
}