@misc{10481/85233,
year = {2023},
month = {9},
url = {https://hdl.handle.net/10481/85233},
abstract = {Colon cancer is the third most frequent neoplasm and the second most lethal worldwide.
Despite progress in its treatment, new therapies are still needed to improve the prognosis of this
type of tumor and, in this context, the use of plant compounds with anti-tumor properties has been
increasing in recent years. The aim of this systematic review was to analyze the potential benefits
of encapsulation of compounds derived from plant extracts in nanoparticles and their cytotoxic
effect under in vitro conditions. Once the search strategy was defined based on the selected MESH
terms, 147 publications published since 2012 were identified from three different databases (PubMed,
SCOPUS and WOS). After eliminating duplicates and applying the inclusion and exclusion criteria,
17 studies were finally included. The results showed that the use of natural extracts encapsulated in
nanoparticles offered significant cytotoxic activity against colon neoplastic cells by increasing the
therapeutic effect of free plant extracts through their encapsulation and without producing toxicity
on healthy cells. In addition, most studies (14) involved metal-derived nanoparticles (zinc, iron and
gold). Despite the possible efficacy of these nanodrugs, more in vivo studies are needed to elucidate
their potential future therapeutic application and their biocompatibility},
organization = {Instituto de Salud Carlos III},
organization = {PI19/01478-FEDER},
organization = {PMPTA22/00136},
organization = {Junta de Andalucía},
organization = {A-CTS-666-UGR20},
organization = {P20_00540},
organization = {B-CTS-122-
UGR20},
organization = {Ministerio de Ciencia e Innovación (RTC2019-006870-1)},
organization = {FEDER},
organization = {CTS-107 (Andalusian Government)},
publisher = {MDPI},
keywords = {Natural extracts},
keywords = {Colorectal cancer},
keywords = {Systematic review},
keywords = {Metallic nanoparticles},
keywords = {Biosynthesis},
title = {Plant-Mediated Inorganic Nanoparticles for Anti-Tumor Therapy in Colorectal Cancer: A Systematic Review},
doi = {10.3390/app131810156},
author = {Mesas Hernández, Cristina and Quiñonero Muñoz, Francisco José and Revuelta Domínguez, Francisco Ignacio and Cabeza Montilla, Laura and Perazzoli, Gloria and Melguizo Alonso, Consolación and Prados Salazar, José Carlos},
}