@misc{10481/85212,
year = {2023},
month = {8},
url = {https://hdl.handle.net/10481/85212},
abstract = {Excessive consumption of added sugars is linked to chronic diseases, such as obesity, diabetes, dyslipidaemia or
cardiovascular disease; and public health is searching for new strategies to reduce it. Although plant-derived
bioactive compounds with inhibitory properties of sweet taste like Gymnema sylvestre show the potential to
reduce sugar intake acutely, their impact after repeated administration is unknown. Therefore, we examined the
changes of single and repeated exposures of a Gymnema sylvestre constituent, gurmarin, in sweet beverage
consumption and preference in a preclinical model. 24 Wistar rats (50 % females) were divided into experimental
(gurmarin) and two control groups (gymnemic acids or phosphate buffer solutions) according to the substances
orally applied. Then acceptance and preference tests with sugar were performed within (Experiment 1) and
between sessions (Experiment 2). We found that administering gurmarin decreased sucrose intake significantly,
even after multiple treatments, without rebound effects. These findings suggest that sweet taste suppressors could
be an effective tool for reducing long-term sugar consumption when repeatedly administrated.},
organization = {FPU Fellowship under Grant
FPU20/02400 (Ministry of Universities, Spain)},
organization = {Grant PID2021-
129042OA-I00},
organization = {MCIN/AEI/10.13039/
501100011033},
organization = {ERDF A way of making Europe},
organization = {Conseil Régional Bourgogne},
organization = {Franche-Comt´e (PARI grant)},
organization = {FEDER (European Funding for Regional Economic Development)},
organization = {Universidad de Granada / CBUA},
publisher = {Elsevier},
keywords = {Biocompound},
keywords = {Gurmarin},
keywords = {Gymnema sylvestre},
keywords = {Sweet taste receptor},
keywords = {Sweet-suppression},
title = {Sweet-inhibiting effects of gurmarin on intake during repeated acute and long-term sugar exposure: A behavioural analysis using an animal model},
doi = {10.1016/j.jff.2023.105743},
author = {Rayo Morales, Raquel and Segura Carretero, Antonio and Poirier, Nicolas and Briand, Loïc and García Burgos, David},
}