@misc{10481/84919,
year = {2023},
month = {8},
url = {https://hdl.handle.net/10481/84919},
abstract = {High-level information processing in the mammalian cortex requires both segregated processing in specialized circuits and integration across multiple circuits. One possible way to implement these seemingly opposing demands is by flexibly switching between states with different levels of synchrony. However, the mechanisms behind the control of complex synchronization patterns in neuronal networks remain elusive. Here, we use precision neuroengineering to manipulate and stimulate networks of cortical neurons in vitro, in combination with an in silico model of spiking neurons and a mesoscopic model of stochastically coupled modules to show that (i) a modular architecture enhances the sensitivity of the network to noise delivered as external asynchronous stimulation and that (ii) the persistent depletion of synaptic resources in stimulated neurons is the underlying mechanism for this effect. Together, our results demonstrate that the inherent dynamical state in structured networks of excitable units is determined by both its modular architecture and the properties of the external inputs.},
organization = {D+i: 
	P20-00173, PID2020-113681GB-I00},
organization = {Innovación y Universidades
	PID2019-108842GB-C21},
organization = {Horizon2020 Future and Emerging Technologies  964877-NEUChiP},
organization = {Ministerio de Ciencia, Innovación y Universidades
(PID2019-108842GB-C21)},
organization = {Departament de Recerca i Universitats, Generalitat de Catalunya
(2017-SGR-1061, 2021-SGR-00450)},
organization = {MICIN/AEI/10.13039/501100011033},
organization = {FEDER “A way to make Europe”},
organization = {Junta de Andalucía},
organization = {European Regional
Development Fund},
publisher = {American Association for the Advancement of Science},
title = {Modular architecture facilitates noise-driven control of synchrony in neuronal networks},
doi = {10.1126/sciadv.ade1755},
author = {Yamamoto, Hideaki and Buendía, Víctor and Muñoz Martínez, Miguel Ángel},
}