@misc{10481/84721,
year = {2023},
month = {8},
url = {https://hdl.handle.net/10481/84721},
abstract = {Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.},
organization = {CRUE-CSIC agreement},
organization = {Spanish government through the Ministry of Universities
	CAS21/00008},
organization = {Spanish University},
organization = {European Union (EU)},
organization = {NextGeneration EU},
organization = {Instituto de Salud Carlos III Spanish Government 13/1944, 16/1288, 17/00663, 19/1338},
organization = {FIS-FSE
	17/00260},
organization = {Miguel Servet-FSE
	MSII20/0006,
	
	FIS-PI06/0867,
	
	FIS-PI09/00090,
	
	CPII18/00018},
organization = {CIBERESP},
organization = {Department of Health of the Basque Government
	2005111093,
	
	2009111069,
	
	2013111089,
	
	2015111065},
organization = {Center for Forestry Research & Experimentation (CIEF)
	BEST/2020/059,
	
	AICO/2020/285,
	
	CIAICO/2021/132},
organization = {Provincial Government of Gipuzkoa
	DFG06/002,
	
	DFG08/001,
	
	DFG15/221,
	
	DFG 89/17},
organization = {Spanish Government},
organization = {State Research Agency
	CEX2018-000806-S},
organization = {Generalitat de Catalunya through the CERCA Program},
publisher = {Springer Nature},
keywords = {Metals},
keywords = {Arsenic speciation},
keywords = {Trace elements},
keywords = {Emotional and behavioral problems},
keywords = {Prenatal exposure},
title = {Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems},
doi = {10.1007/s12403-023-00585-6},
author = {Lozano, Manuel and Gil Hernández, Fernando and Olmedo Palma, Pablo},
}