@misc{10481/84560,
year = {2023},
month = {8},
url = {https://hdl.handle.net/10481/84560},
abstract = {Introduction: Previous studies measuring intervals on the oral cancer care
pathway have been heterogenous, showing mixed results with regard to patient
outcomes. The aims of this research were (1) to calculate pooled meta-analytic
estimates for the duration of the patient, diagnostic and treatment intervals in
oral cancer, considering the income level of the country, and (2) to review the
evidence on the relationship of these three intervals with tumor stage at diagnosis
and survival.
Materials and methods: We conducted a systematic review with meta-analysis
following PRISMA 2020 guidelines (pre-registered protocol CRD42020200752).
Following the Aarhus statement, studies were eligible if they reported data on
the length of the patient (first symptom to first presentation to a healthcare
professional), diagnostic (first presentation to diagnosis), or treatment (diagnosis
to start of treatment) intervals in adult patients diagnosed with primary oral
cancer. The risk of bias was assessed with the Aarhus checklist.
Results: Twenty-eight studies reporting on 30,845 patients met the inclusion
criteria. The pooled median duration of the patient interval was 47 days (95%
CI = 31–73), k = 18, of the diagnosis interval 35 days (95% CI = 21–38),k = 11,
and of the treatment interval 30 days (95% CI = 23–53), k = 19. In lower-income
countries, the patient and treatment intervals were significantly longer, and
longer patient intervals were related to later stage at diagnosis. In studies with a
lower risk of bias from high-income countries, longer treatment intervals were
associated with lower survival rates.
Conclusion: Interval duration on the oral cancer care pathway is influenced by
the socio-economic context and may have implications for patient outcomes.},
organization = {Asociación Española contra el Cáncer, PROYE20023SANC},
organization = {Cancer Epidemiological Surveillance
Subprogram of the CIBER of Epidemiology and Public Health},
organization = {Health Institute Carlos III (VICA)},
organization = {Health Institute
Carlos III: PI18/01593},
organization = {MCIN/AEI, JC2019-039691-I},
publisher = {Frontiers Media},
keywords = {Oral cancer},
keywords = {Intervals},
keywords = {Early diagnosis},
keywords = {TNM staging},
keywords = {Survival},
title = {The duration of intervals on the oral cancer care pathway and implications for survival: a systematic review and meta-analysis},
doi = {10.3389/fpubh.2023.1183244},
author = {Fernández-Martínez, Nicolás Francisco and Barrios Rodríguez, Rocío and Martín de los Reyes, Luis Miguel and Rodríguez Barranco, Miguel and Sánchez Pérez, María José},
}