@misc{10481/84528,
year = {2023},
month = {7},
url = {https://hdl.handle.net/10481/84528},
abstract = {Inflammatory bowel disease (IBD) is a public health challenge and the use of pectin for symptom amelioration is
a promising option. In this work, sunflower pectin has been extracted without (CHP) and with assistance of
ultrasound (USP) using sodium citrate as a food-grade extracting agent. At optimal conditions (64 ◦C, 23 min) the
highest yield was obtained with ultrasound application (15.5 vs. 8.1 %). Both pectins were structurally characterized
by 1H NMR, HPSEC-ELSD, FT-IR and GC-FID. Unlike CHP, USP showed a lower molecular weight,
higher galacturonic acid, lower degree of methyl-esterification and, overall, higher viscosity. These characteristics
could affect the anti-inflammatory activity of pectins, evaluated using DSS-induced IBD model mice. So,
USP promoted the defence (ICAM-1) and repair of the gastrointestinal mucosa (TFF3, ZO-1) more effectively than
CHP. These results demonstrate the potential amelioration of acute colitis in IBD mice through USP supplementation.
Taking into account the biomarkers analysed, these results demonstrate, for the first time, the positive
impact of sunflower pectin extracted by ultrasound under very soft conditions on inflammatory bowel disease
that might open up new possibilities in the treatment of this serious pathology},
organization = {MINECO of Spain, Project AGL2014-
53445-R},
organization = {Grant PID2021-123862OB-I00 funded by MCIN/AEI/
10.13039/501100011033},
organization = {ERDF A way of making Europe},
organization = {PFIS (FI20/00159) from the Instituto
de Salud Carlos III},
organization = {Ministry of Economy of
Spain},
publisher = {Elsevier},
keywords = {Sunflower pectin},
keywords = {Structural characterization},
keywords = {Galacturonic acid},
keywords = {Degree of methyl-esterification},
keywords = {Low-methoxyl pectin},
keywords = {Anti-inflammatory effect},
title = {Pectin from sunflower by-products obtained by ultrasound: Chemical characterization and in vivo evaluation of properties in inflammatory bowel disease},
doi = {10.1016/j.ijbiomac.2023.125505},
author = {Muñoz Almagro, Nerea and Molina Tijeras, José Alberto and Vezza, Teresa},
}