@misc{10481/84426,
year = {2023},
month = {8},
url = {https://hdl.handle.net/10481/84426},
abstract = {Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent regarding the potential benefits of nuts for cognitive function.Objective: To prospectively evaluate the association between nut consumption and 2-y changes in cognitive performance in older adults at cognitive decline risk.Methods: A total of 6,630 participants aged 55 to 75 y (mean age 65.0 & PLUSMN;4.9 y, 48.4% women) with overweight/obesity and metabolic syndrome completed a validated semi-quantitative food frequency questionnaire and a comprehensive battery of neuropsychological tests at baseline and a 2-y follow-up. Composite cognitive scores were used to assess global, general, attention, and executive function domains. Nut consumption was categorized as <1, >1 to <3, >3 to <7, and >7 servings/wk (1 serving=30 g). Multivariable-adjusted linear regression models were fitted to assess associations between baseline nut consumption and 2-y cognitive changes.Results: Nut consumption was positively associated with 2-y changes in general cognitive function (P-trend <0.001). Compared with participants consuming <1 serving/wk of nuts, those categorized as consuming >3 to <7 and >7 servings/wk showed more favorable changes in general cognitive performance (& beta; z-score [95% CI] = 0.06 [0.00,0.12] and 0.13 [0.06,0.20], respectively). No significant changes were observed in the multivariableadjusted models for other cognitive domains assessed.Conclusion: Frequent nut consumption was associated with a smaller decline in general cognitive performance over 2 y in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted.},
organization = {Official Spanish Institutions},
organization = {Instituto de Salud Carlos III (ISCIII) , Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund
	PI13/00673,
	
	PI13/00492,
	
	PI13/00272,
	
	PI13/01123,
	
	PI13/00462,
	
	PI13/00233,
	
	PI13/02184,
	
	PI13/00728,
	
	PI13/01090,
	
	PI13/01056,
	
	PI14/01722,
	
	PI14/00636,
	
	PI14/00618,
	
	PI14/00696,
	
	PI14/01206,
	
	PI14/01919,
	
	PI14/00853,
	
	PI14/01374,
	
	PI14/00972,
	
	PI14/00728,
	
	PI14/01471,
	
	PI16/00473,
	
	PI16/00662,
	
	PI16/01873,
	
	PI16/01094,
	
	PI16/00501,
	
	PI16/00533,
	
	PI16/00381,
	
	PI16/00366,
	
	PI16/01522,
	
	PI16/01120,
	
	PI17/00764,
	
	PI17/01183,
	
	PI17/00855,
	
	PI17/01347,
	
	PI17/00525,
	
	PI17/01827,
	
	PI17/00532,
	
	PI17/00215,
	
	PI17/01441,
	
	PI17/00508,
	
	PI17/01732,
	
	PI17/00926,
	
	PI19/00957,
	
	PI19/00386,
	
	PI19/00309,
	
	PI19/01032,
	
	PI19/00576,
	
	PI19/00017,
	
	PI19/01226,
	
	PI19/00781,
	
	PI19/01560,
	
	PI19/01332,
	
	PI20/01802,
	
	PI20/00138,
	
	PI20/01532,
	
	PI20/00456,
	
	PI20/00339,
	
	PI20/00557,
	
	PI20/00886,
	
	PI20/01158},
organization = {La Caixa Foundation
	2013ACUP00194},
organization = {Junta de Andalucía PI0458/2013, PS0358/2016, PI0137/2018, PROMETEO/2017/017},
organization = {Conselleria de Innovación, Universidades
	PID2019-108858RB-I00,
	
	AICO/2021/347},
organization = {Center for Forestry Research & Experimentation (CIEF) EU-H2020: Eat2beNICE/H2020-SFS-2016-2},
organization = {Horizon 2020 PRIME study 847879},
organization = {Spanish Government
	FPU 20/00385},
organization = {Ministerio de Ciencia, Innovación y Universidades FPU 20/00385},
organization = {Canadian Institutes of Health Research (CIHR)},
organization = {ICREA under the ICREA Academia program},
publisher = {Elsevier},
keywords = {Aging},
keywords = {Nuts},
keywords = {Unsaturated fatty acids},
keywords = {Cognitive decline},
keywords = {Cognition},
keywords = {Older people},
title = {Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study},
doi = {10.1016/j.ajcnut.2023.05.032},
author = {Ni, Jiaqi and Cano Ibáñez, Naomi and Martínez Diz, Silvia and Predimed-Plus Investigators},
}