@misc{10481/84037,
year = {2023},
month = {6},
url = {https://hdl.handle.net/10481/84037},
abstract = {Developing new types of effective antimicrobial compounds derived from natural products
is of interest for the food industry. Some analogs to A-type proanthocyanidins have shown promising
antimicrobial and antibiofilm activities against foodborne bacteria. We report herein the synthesis
of seven additional analogs with NO2 group at A-ring and their abilities for inhibiting the growth
and the biofilm formation by twenty-one foodborne bacteria. Among them, analog 4 (one OH at
B-ring; two OHs at D-ring) showed the highest antimicrobial activity. The best results with these
new analogs were obtained in terms of their antibiofilm activities: analog 1 (two OHs at B-ring; one
OH at D-ring) inhibited at least 75% of biofilm formation by six strains at all of the concentrations
tested, analog 2 (two OHs at B-ring; two OHs at D-ring; one CH3 at C-ring) also showed antibiofilm
activity on thirteen of the bacteria tested, and analog 5 (one OH at B-ring; one OH at D-ring) was able
to disrupt preformed biofilms in eleven strains. The description of new and more active analogs of
natural compounds and the elucidation of their structure-activity relationships may contribute to the
active development of new food packaging for preventing biofilm formation and lengthening the
food shelf life.},
organization = {Andalusian Consejería de Economía y Conocimiento
(FEDER program 2014–2020: grant number 1380669),},
organization = {Spain, and the Spanish Ministerio de Ciencia},
organization = {Innovación y Universidades (grant RTI2018-098560-B-C22,},
organization = {FEDER funds of the
European Union)},
organization = {(Grant RTI2018-098560-B-C22, co-financed by the FEDER funds of the
European Union},
organization = {Centro de Instrumentación Científico-Técnica
(CICT) of the University of Jaén, Spain.},
publisher = {MDPI},
keywords = {A-type proanthocyanidin analogs},
keywords = {Flavylium chemistry},
keywords = {Antimicrobial activity},
keywords = {Antibiofilm activity},
keywords = {Antioxidant activity},
title = {Synthesis of Analogs to A-Type Proanthocyanidin Natural Products with Enhanced Antimicrobial Properties against Foodborne Microorganisms},
doi = {10.3390/molecules28124844},
author = {Cobo Molinos, Antonio},
}