@misc{10481/83914,
year = {2023},
month = {6},
url = {https://hdl.handle.net/10481/83914},
abstract = {The increased consumption of blue-green algae (BGA)-based dietary supplements has raised concern about their food safety, especially about cyanotoxin presence. The hyphenation of liquid chromatography with ion mobility mass spectrometry represents a relevant tool to screen several compounds in a large variety of food matrices. In this work, ultrahigh-performance liquid chromatography coupled to traveling wave ion mobility spectrometry/quadrupole time-of-flight mass spectrometry (UHPLC-TWIMS-QTOF) was employed to establish the first comprehensive TWIMS-derived collision cross section database (TWCCSN2) for phycotoxins. The database included 20 cyanotoxins and 1 marine toxin. Accurate m/z, retention times, and TWCCSN2 values were obtained for 81 adducts in positive and negative electrospray (ESI+/ESI–) modes. Reproducibility and robustness of the TWCCSN2 measurements were determined to be independent of the matrix. A screening was carried out on 19 commercial BGA dietary supplements of different composition. Cyanotoxins were confidently identified in five samples based on retention time, m/z, and TWCCSN2.},
organization = {The University of
Parma through the action Bando di Ateneo 2021},
organization = {MUR-Italian Ministry of Universities and
Research-D.M. 737/2021-PNR-PNRR−NextGenerationEU,
(ii) from the Project PID2021-127804OB-I00},
organization = {Spanish MCIN/AEI/10.13039/501100011033},
organization = {ERDF A way of making Europe” and from the Andalousian
Government (Project ref. PROYEXCEL_00195)},
organization = {The Grant (FPU17/03810) financed by MCIN/AEI/
10.13039/501100011033, by “ESF Investing in your future”.},
organization = {Grant IJC2019-040989-I funded by
MCIN/AEI/10.13039/501100011033},
organization = {Waters Italy for providing the Atlantis Premier
BEH Z-HILIC column},
publisher = {ACS Publications},
keywords = {Ion mobility-mass spectrometry},
keywords = {Collision cross section},
keywords = {Cyanotoxins},
keywords = {Phycotoxins},
keywords = {CCS database},
keywords = {BGA dietary supplements},
title = {Implementing the Use of Collision Cross Section Database for Phycotoxin Screening Analysis},
doi = {10.1021/acs.jafc.3c01060},
author = {Aparicio Muriana, María del Mar and Lara Vargas, Francisco Jesús and Olmo Iruela, María Monsalud Del and Hernández Mesa, Maykel and García Campaña, Ana María and Righetti, Laura},
}