@misc{10481/83865,
year = {2023},
month = {5},
url = {https://hdl.handle.net/10481/83865},
abstract = {Objective: Phenylcapsaicin (PC) is a new capsaicin analog which has exhibited a
higher bioavailability. This sudy assessed the effects of a low dose (LD) of 0.625 mg
and a high dose (HD) of 2.5 mg of PC on aerobic capacity, substrate oxidation,
energy metabolism and exercise physiological variables in young males.
Materials and methods: Seventeen active males (age = 24.7 ± 6.0 years) enrolled
to this randomized, triple-blinded, placebo-controlled, crossover trial.
Participants attended the laboratory on 4 sessions separated by 72–96 h. A
submaximal exercise test [to determine maximal fat oxidation (MFO) and the
intensity at MFO (FATmax)] followed by a maximal incremental test (to determine
VO2max) were performed in a preliminary session. The subsequent sessions only
differed in the supplement ingested [LD, HD or placebo (PLA)] and consisted of a
steady-state test (60 min at FATmax) followed by a maximal incremental test.
Energy metabolism, substrate oxidation, heart rate, general (gRPE) and quadriceps
(RPEquad) rate of perceived exertion, skin temperature and thermal perception
were tested.
Results: Clavicle thermal perception was lower in HD compared to PLA and LD
(p = 0.04) across time. HD reduced maximum heart rate in comparison to PLA and
LD (p = 0.03). LD reported higher general RPE (RPEg) values during the steadystate
test compared to PLA and HD across time (p = 0.02). HD and LD elicited
higher peak of fat oxidation during the steady-state test compared with PLA (p =0.05). Intra-test analyses revealed significant differences for fat oxidation (FATox) in
favor of HD and LD compared to PLA (p = 0.002 and 0.002, respectively), and for
carbohydrate oxidation (CHOox) (p = 0.05) and respiratory exchange ratio (RER)
(p = 0.03) for PLA. In the incremental test, only general RPE at 60% of the maximal
intensity (W) differed favoring HD (p ≤ 0.05).
Conclusion: Therefore, PC may contribute to increase aerobic capacity through
the improvement of fat oxidation, maximum heart rate and perceptual responses
during exercise.},
publisher = {Frontiers},
keywords = {Substrate oxidation},
keywords = {Ergogenic aid},
keywords = {Exercise metabolism},
keywords = {Exercise capacity},
title = {Effects of phenylcapsaicin on aerobic capacity and physiological parameters in active young males: a randomized, triple-blinded, placebo-controlled, crossover trial},
doi = {10.3389/fphys.2023.1190345},
author = {Jiménez Martínez, Pablo and Osuna Prieto, Francisco Javier and Jurado Fasoli, Lucas and Amaro Gahete, Francisco José},
}