@misc{10481/83815,
year = {2023},
month = {5},
url = {https://hdl.handle.net/10481/83815},
abstract = {Vanadium (V) is a trace mineral whose biological activity, role as a micronutrient, and pharmacotherapeutic
applications remain unknown. Over the last years, interest in V has increased due
to its potential use as an antidiabetic agent mediated by its ability to improve glycemic metabolism.
However, some toxicological aspects limit its potential therapeutic application. The present study
aims to evaluate the effect of the co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV)
(BMOV) as a possible strategy to reduce the toxicity of BMOV. Treating hepatic cells with BMOV
reduced cell viability under the present conditions, but cell viability was corrected when cells were
co-incubated with BMOV and Cu. Additionally, the effect of these two minerals on nuclear and
mitochondrial DNA was evaluated. Co-treatment with both metals reduced the nuclear damage
caused by BMOV. Moreover, treatment with these two metals simultaneously tended to reduce the
ND1/ND4 deletion of the mitochondrial DNA produced with the treatment using BMOV alone.
In conclusion, these results showed that combining Cu and V could effectively reduce the toxicity
associated with V and enhance its potential therapeutic applications.},
organization = {Consejería de Innovación,
Ciencia y Empresa, Andalusian Regional Government (Project P06-CTS-01435),},
organization = {The Spanish
Ministry of Economy and Competitivity (SAF2011-29648)},
publisher = {MDPI},
keywords = {Vanadium},
keywords = {Copper},
keywords = {Mineral},
keywords = {Nutrition},
keywords = {Mitochondria},
keywords = {DNA},
title = {Elucidating the Therapeutic Potential of Bis(Maltolato)OxoVanadium(IV): The Protective Role of Copper in Cellular Metabolism},
doi = {10.3390/ ijms24119367},
author = {Rivas García, Lorenzo and Varela López, Alfonso and Quiles Morales, José Luis and Montes Bayón, María and Aranda Ramírez, Pilar and Llopis González, Juan and Sánchez González, Cristina},
}