@misc{10481/82941,
year = {2023},
month = {4},
url = {https://hdl.handle.net/10481/82941},
abstract = {Objectives: Fat depots localization has a critical role in the metabolic health
status of adults. Nevertheless, whether that is also the case in children remains
under-studied.
Therefore, the aims of this study were: (i) to examine the differences
between metabolically healthy (MHO) and unhealthy (MUO) overweight/
obesity phenotypes on specific abdominal fat depots, and (ii) to further explore
whether cardiorespiratory fitness plays a major role in the differences between
metabolic phenotypes among children with overweight/obesity.
Methods: A total of 114 children with overweight/obesity (10.6 ± 1.1 years, 62
girls) were included. Children were classified as MHO (n = 68) or MUO. visceral
(VAT), abdominal subcutaneous (ASAT), intermuscular abdominal (IMAAT),
psoas, hepatic, pancreatic, and lumbar bone marrow adipose tissues were measured by magnetic resonance imaging. Cardiorespiratory fitness was assessed
using the 20 m shuttle run test.
Results: MHO children had lower VAT and ASAT contents and psoas fat
fraction compared to MUO children (difference = 12.4%–25.8%,
all p < 0.035).
MUO-unfit
had more VAT and ASAT content than those MUO-fit
and MHO-fit
(difference = 34.8%–45.3%,
all p < 0.044). MUO-unfit
shows also greater IMAAT
fat fraction than those MUO-fit
and MHO-fit
peers (difference = 16.4%–13.9%
respectively, all p ≤ 0.001). In addition, MHO-unfit
presented higher IMAAT
fat fraction than MHO-fit
(difference = 13.4%, p < 0.001). MUO-unfit
presented
higher psoas fat fraction than MHO-fit
(difference = 29.1%, p = 0.008).
Conclusions: VAT together with ASAT and psoas fat fraction, were lower in
MHO than in MUO children. Further, we also observed that being fit, regardless
of metabolic phenotype, has a protective role over the specific abdominal fat depots
among children with overweight/obesity.},
organization = {Spanish Ministry of
Health “Fondos de Investigación Sanitaria del Instituto
de Salud Carlos III” (PI13/01335)},
organization = {EU Fondos Estructurales de la Unión Europea
(FEDER) funds (“Una manera de hacer Europa”)},
organization = {Department of
Economic Development of the Government of Navarra
(0011-1365-
2019-
000085)},
organization = {Spanish Ministry of Science and
Innovation (FJC2018-037925-
I)},
organization = {European Union's Horizon 2020 research and innovation
programme under the Marie Sklodowska Curie
grant agreement No. 101028929},
organization = {European Union NextGeneration EU and
the Spanish Ministry of Universities (postdoctoral fellowship
Margarita Salas, 572827-MS15)},
publisher = {Wiley},
keywords = {Abdominal subcutaneous fat},
keywords = {Aerobic capacity},
keywords = {Hepatic fat},
keywords = {Lumbar bone marrow fat},
keywords = {Psoas fat},
keywords = {Visceral fat},
keywords = {Youth},
title = {Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: The role of cardiorespiratory fitness},
doi = {10.1111/sms.14372},
author = {Cadenas Sánchez, Cristina and Ortega Porcel, Francisco Bartolomé},
}