@misc{10481/82702,
year = {2023},
month = {5},
url = {https://hdl.handle.net/10481/82702},
abstract = {Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.},
organization = {CIBER-OBN
	G03/140, PI10/02293, PI10/02658, PI13/00615, PI14/01668, PI14/01764, PI14/01798, PI17/01795, PI18/00631, PI20/00564},
organization = {Government-Instituto de Salud Carlos III},
organization = {Hershey's},
organization = {Harvard University},
organization = {Plan Nacional sobre Drogas 2020/021  PNSD},
organization = {Federación Española de Enfermedades Raras  RD 06/0045	FEDER},
organization = {Universidad de Navarra 010830},
organization = {European Regional Development Fund  ERDF},
organization = {Gobierno de Navarra 122/2014, 27/2011, 45/2011},
publisher = {Elsevier},
keywords = {Health-related quality of life},
keywords = {Mortality},
keywords = {SF-36},
keywords = {Cohort},
keywords = {SUN Project},
title = {Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study},
doi = {10.1016/j.exger.2023.112224},
author = {López-Herreros, J. and Jiménez Moleón, José Juan},
}