@misc{10481/82526,
year = {2023},
url = {https://hdl.handle.net/10481/82526},
abstract = {The pharmaceutical cocrystal landscape of ethenzamide has been addressed during the past years with the
aim of improving its physicochemical properties, mainly solubility and dissolution rate. Herein four novel
ethenzamide cocrystals have been isolated by mechanochemical synthesis and thoroughly characterized
by powder and single-crystal X-ray diffraction. Polyphenols have been selected as coformers based on
ethenzamide synthon preference as well as their safety profile and antioxidant character. Besides
crystallographic analysis, theoretical calculations have been made to evaluate the strength of
intermolecular interactions and their role in crystal packing. The results evidence differences in the
supramolecular architecture depending on the different polyphenolic isomers used as coformers. Finally,
the physicochemical properties of the novel compounds were assessed and compared to those of
ethenzamide alone. Although the solubility profile is significantly enhanced, the thermodynamic stability of
the novel cocrystals in aqueous medium is restricted to 24 hours. These findings have been correlated with
the crystal structure.},
organization = {FEDER-Universidad de Granada, Spain	B-FQM-478-UGR20},
organization = {Spanish Government	PID2020-115637GB-I00},
organization = {European Commission},
organization = {Spanish Government	PRE2019-088832},
publisher = {Royal Society of Chemstry},
title = {Evaluation of synthon influence on ethenzamide– polyphenol pharmaceutical cocrystals},
doi = {10.1039/d3ce00234a},
author = {Acebedo Martínez, Francisco Javier and Domínguez Martín, Alicia and Alarcón Payer, Carolina and Frontera, Antonio and Ibáñez, Ángel and Choquesillo Lazarte, Duane},
}