@misc{10481/82343,
year = {2023},
url = {https://hdl.handle.net/10481/82343},
abstract = {In humans, even where millions of spermatozoa are deposited upon ejaculation in the vagina, only a few thousand
enter the uterine tube (UT). Sperm transiently adhere to the epithelial cells lining the isthmus reservoir,
and this interaction is essential in coordinating the availability of functional spermatozoa for fertilization. The
binding of spermatozoa to the UT epithelium (mucosa) occurs due to interactions between cell-adhesion
molecules on the cell surfaces of both the sperm and the epithelial cell. However, in humans, there is little information
about the molecules involved. The aim of this study was to perform a histological characterization of
the UT focused on determining the tissue distribution and deposition of some molecules associated with cell
adhesion (F-spondin, galectin-9, osteopontin, integrin αV/β3) and UT’s contractile activity (TNFα-R1, TNFα-
R2) in the follicular and luteal phases. Our results showed the presence of galectin-9,
F-spondin, osteopontin, integrin αV/β3, TNFα-R1, and TNFα-R2 in the epithelial cells in ampullar and isthmic
segments during the menstrual cycle. Our results suggest that these molecules could form part of the sperm-UT
interactions. Future studies will shed light on the specific role of each of the identified molecules},
organization = {Universidad de Santiago de Chile (USACH), Agradecimientos Proyecto Dicyt	022201GG},
organization = {Vicerrectoia de Investigacion, Desarrollo e Innovacion and the Tissue Engineering Group	CTS -115},
organization = {Department of Histology, University of Granada, Spain},
organization = {ANID Nacional Becas/doctorado	21191519},
publisher = {National Library of Medicine},
keywords = {Human uterine tube},
keywords = {Epitheliummenstrual cycle},
keywords = {Immunohistochemistry},
keywords = {Cell adhesion molecules},
title = {Molecules involved in the sperm interaction in the human uterine tube: a histochemical and immunohistochemical approach},
doi = {10.4081/ejh.2023.3513},
author = {Cajas, David and Carriel Araya, Víctor and Campos Muñoz, Antonio Jesús},
}