@misc{10481/82325,
year = {2023},
month = {3},
url = {https://hdl.handle.net/10481/82325},
abstract = {dibenzop-
furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors
and have been associated with different chronic diseases such as diabetes and hypertension. However, studies
assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged
population are limited.
Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of
PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and
abdominal obesity in a middle-aged population.
Methods: In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the
PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire,
and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective
associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were
assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models.
Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher
BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference
(1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05
[1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants
in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in
the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015).
Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at
baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/
obesity. Further large prospective studies using a different population with longer follow-up periods are warranted
in the future to strengthen our results.},
organization = {nstituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund	PI16/01120
PI17/00764
PI17/01183
PI17/00855
PI17/01347
PI17/00525
PI17/01827
PI17/00532
PI17/00215
PI17/01441
PI17/00508
PI17/01732
PI17/00926
PI19/00957
PI19/00386
PI19/00309
PI19/01032
PI19/00576
PI19/00017
PI19/01226
PI19/00781
PI19/01560
PI19/01332
PI20/01802
PI20/00138
PI20/01532
PI20/00456
PI20/00339
PI20/00557
PI20/00886
PI20/01158},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)},
organization = {Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant},
organization = {European Research Council (ERC)
European Commission	340918},
organization = {La Caixa Foundation	2013ACUP00194},
organization = {Junta de Andalucia	PI0458/2013
PS0358/2016
PI0137/2018},
organization = {Center for Forestry Research & Experimentation (CIEF)	PROMETEO/21/2021},
organization = {MICIN/AEI/FEDER, UE	CEX2021-001234-M},
organization = {SEMERGEN grant},
organization = {ICREA under the ICREA Academia program},
organization = {Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR FI)	2021FI_B 00145},
keywords = {Polychlorinated dibenzo-p-furans (PCDD/F)},
keywords = {Adiposity},
keywords = {Obesity},
keywords = {Abdominal obesity},
keywords = {Endocrine disrupting chemicals},
title = {Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status},
doi = {10.1016/j.envres.2023.115697},
author = {Khoury, Nadine and Bueno Cavanillas, Aurora and Salcedo Bellido, Inmaculada},
}