@misc{10481/82300,
year = {2023},
month = {4},
url = {https://hdl.handle.net/10481/82300},
abstract = {Sarcomas are a diverse group of neoplasms with an incidence rate of 15% of childhood
cancers. They exhibit a high tendency to develop early metastases and are often resistant to available
treatments, resulting in poor prognosis and survival. In this context, cancer stem cells (CSCs) have
been implicated in recurrence, metastasis, and drug resistance, making the search for diagnostic and
prognostic biomarkers of the disease crucial. The objective of this systematic review was to analyze
the expression of CSC biomarkers both after isolation from in vitro cell lines and from the complete
cell population of patient tumor samples. A total of 228 publications from January 2011 to June 2021
was retrieved from different databases, of which 35 articles were included for analysis. The studies
demonstrated significant heterogeneity in both the markers detected and the CSC isolation techniques
used. ALDH was identified as a common marker in various types of sarcomas. In conclusion, the
identification of CSC markers in sarcomas may facilitate the development of personalized medicine
and improve treatment outcomes.},
organization = {CTS-107 (Andalusian Government)},
publisher = {MDPI},
keywords = {Sarcomas},
keywords = {Cancer stem cells},
keywords = {Biomarkers},
keywords = {Systematic review},
title = {Cancer Stem Cells in Sarcomas: In Vitro Isolation and Role as Prognostic Markers: A Systematic Review},
doi = {10.3390/cancers15092449},
author = {Chico Lozano, María Ángeles and Mesas Hernández, Cristina and Quiñonero Muñoz, Francisco José and Perazzoli, Gloria and Ortiz Quesada, Raúl and Prados Salazar, José Carlos and Melguizo Alonso, Consolación},
}