@misc{10481/82286,
year = {2023},
month = {4},
url = {https://hdl.handle.net/10481/82286},
abstract = {Obesity is a global health issue, in which modifications in gut microbiota composition
have a key role. Different therapeutic strategies are being developed in combination with diet and
exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent
studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present
work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced
obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight
gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were
associated with an amelioration of the obesity-associated inflammatory status, most probably due
to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated
gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the
decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced
Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial
effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic
effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis.},
organization = {Junta de Andalucia	CTS 164},
organization = {Instituto de Salud Carlos III	PI19.01058},
organization = {Spanish Government	AGL2015-67995-C3-3-R},
organization = {perational Programme of the Region of Murcia (CCI)	2007ES161PO001
14-20/20},
organization = {European Commission},
organization = {Instituto de Salud Carlos III},
organization = {i-pFIS, Instituto de Salud Carlos III; Programa de Doctorado Biomedicina},
organization = {pFIS, Instituto de Salud Carlos III; Programa de Doctorado Nutricion},
publisher = {MDPI},
keywords = {Morus alba L},
keywords = {Obesity},
keywords = {Microbiota},
keywords = {Antioxidant},
title = {The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice},
doi = {10.3390/antiox12040978},
author = {Rodríguez Sojo, María Jesús and Ruiz Malagón, Antonio Jesús and Hidalgo García, Laura and Molina Tijeras, José Alberto and Díez Echave, Patricia and López Escánez, Laura and González Lozano, Elena and García García, Jorge and Robles Vera, Iñaki and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel and Gálvez Peralta, Julio Juan and Rodríguez Cabezas, María Elena and Rodríguez Nogales, Alba},
}