@misc{10481/82281,
year = {2023},
month = {3},
url = {https://hdl.handle.net/10481/82281},
abstract = {Obesity is a worldwide public health problem whose prevalence rate has increased steadily
over the last few years. Therefore, it is urgent to improve the management of obesity and its
comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this
regard, the present study aimed to investigate a well-characterized extract of Lavandula multifida (LME)
in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly,
the daily administration of LME reduced weight gain as well as improved insulin sensitivity and
glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose
tissue by decreasing the expression of various proinflammatory mediators (Il-6, Tnf-a, Il-1b, Jnk-1,
Ppara, Pparg, and Ampk) and prevented increased gut permeability by regulating the expression of
mucins (Muc-1, Muc-2, and Muc-3) and proteins implicated in epithelial barrier integrity maintenance
(Ocln, Tjp1, and Tff-3). In addition, LME showed the ability to reduce oxidative stress by inhibiting
nitrite production on macrophages and lipid peroxidation. These results suggest that LME may
represent a promising complementary approach for the management of obesity and its comorbidities.},
organization = {Junta de Andalucía (CTS 164), by the Instituto de Salud
Carlos III (ISCIII) (PI19.01058)},
organization = {Spanish Ministry of Economy and Competitiveness
(AGL2015-67995-C3-3-R)},
organization = {European Commission (FEDER/ERDF). The CIBEREHD},
organization = {Instituto de Salud Carlos III},
publisher = {MDPI},
keywords = {Obesity},
keywords = {High-fat diet},
keywords = {Insulin resistance},
keywords = {Inflammation},
keywords = {Lavandula multifida},
title = {The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice},
doi = {10.3390/ antiox12040832},
author = {Molina Tijeras, José Alberto and Ruiz Malagón, Antonio Jesús and Hidalgo García, Laura and Díez Echave, Patricia and Rodríguez Sojo, María Jesús and Cádiz Gurrea, María de la Luz and Segura Carretero, Antonio and Rodríguez Cabezas, María Elena and Gálvez Peralta, Julio Juan and Rodríguez Nogales, Alba and Vezza, Teresa and Algieri, Francesca},
}