@misc{10481/82277,
year = {2023},
month = {4},
url = {https://hdl.handle.net/10481/82277},
abstract = {Bisphenols, parabens (PBs), and benzophenones (BPs) are widely used environmental
chemicals that have been linked to several adverse health effects due to their endocrine disrupting
properties. However, the cellular pathways through which these chemicals lead to adverse outcomes
in humans are still unclear, suggesting some evidence that inflammation might play a key role. Thus,
the aim of this study was to summarize the current evidence on the relationship between human
exposure to these chemicals and levels of inflammatory biomarkers. A systematic review of peer-
reviewed original research studies published up to February 2023 was conducted using the MEDLINE,
Web of Science, and Scopus databases. A total of 20 articles met the inclusion/exclusion criteria. Most
of the reviewed studies reported significant associations between any of the selected chemicals (mainly
bisphenol A) and some pro-inflammatory biomarkers (including C-reactive protein and interleukin 6,
among others). Taken together, this systematic review has identified consistent positive associations
between human exposure to some chemicals and levels of pro-inflammatory biomarkers, with very
few studies exploring the associations between PBs and/or BPs and inflammation. Therefore, a larger
number of studies are required to get a better understanding on the mechanisms of action underlying
bisphenols, PBs, and BPs and the critical role that inflammation could play.},
organization = {European Commission (EU's Horizon Europe research and innovation programme)
	101057014},
organization = {Instituto de Salud Carlos III
Spanish Government
	FIS PI17/01743},
organization = {Antonio Chamorro/Alejandro Otero' Research Chair},
organization = {Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP)},
organization = {Instituto de Salud Carlos III
	IFI18/00052,
	
	FI17/00316},
publisher = {MDPI},
keywords = {Bisphenol},
keywords = {Paraben},
keywords = {Benzophenone},
keywords = {Human},
keywords = {Exposure},
keywords = {Inflammation},
title = {Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review},
doi = {10.3390/ijms24087325},
author = {Peinado Rodríguez, Francisco Manuel and Iribarne Durán, Luz María and Artacho Cordón, Francisco},
}