@misc{10481/82150,
year = {2023},
url = {https://hdl.handle.net/10481/82150},
abstract = {Objective: (1) to determine the effects of the silver diamine fluoride (SDF) and sodium fluoride (NaF) in demineralized dentin exposed to an acid challenge by pH-cycling, (2) to evaluate the remineralizing capacity of SDF/NaF products based on the physicochemical and mechanical properties of the treated dentin surfaces. Methodology: In total, 57 human molars were evaluated in different stages of the experimental period: sound dentin - negative control (Stage 1), demineralized dentin - positive control (Stage 2), and dentin treated with SDF/ NaF products + pH-c (Stage 3). Several commercial products were used for the SDF treatment: Saforide, RivaStar, and Cariestop. The mineral composition and crystalline and morphological characteristics of the dentin samples from each experimental stage were evaluated by infrared spectroscopy (ATR-FTIR), X-ray diffraction, and electron microscopy (SEM-EDX) analytical techniques. Moreover, the mechanical response of the samples was analyzed by means of the three-point bending test. Statistics were estimated for ATR-FTIR variables by Wilcoxon test, while the mechanical data analyses were performed using Kruskal-Wallis and Mann Whitney U tests. Results: Regarding the chemical composition, we observed a higher mineral/organic content in the SDF/NaF treated dentin + pH-c groups (Stage 3) than in the positive control groups (Saforide p=0.03; Cariestop p=0.008; RivaStar p=0.013; NaF p=0.04). The XRD results showed that the crystallite size of hydroxyapatite increased in the SDF/NaF treated dentin + pH-c groups (between +63% in RivaStar to +108% in Saforide), regarding the positive control. SEM images showed that after application of the SDF/NaF products a crystalline precipitate formed on the dentin surface and partially filled the dentin tubules. The flexural strength (MPa) values were higher in the dentin treated with SDF/NaF + pH-c (Stage 3) compared to the positive control groups (Saforide p=0.002; Cariestop p=0.04; RivaStar p=0.04; NaF p=0.02). Conclusions: The application of SDF/ NaF affected the physicochemical and mechanical properties of demineralized dentin. According to the results, the use of SFD/NaF had a remineralizing effect on the dentin surface even under acid challenge.},
organization = {Spanish Government
	PID2020-116660GB-I00},
organization = {European Commission
	A-RNM-408-UGR20},
organization = {European Regional Development Fund (ERDF) - Next Generation/EU program},
publisher = {Universidad Sao Paulo Facultdad de Odontología Bauru},
keywords = {Dentin},
keywords = {Sodium fluoride},
keywords = {Biomineralization},
keywords = {Dental caries},
keywords = {Silver compounds},
keywords = {Silver diamine},
keywords = {Crystallization},
title = {Evaluation of the remineralizing capacity of silver diamine fluoride on demineralized dentin under pH-cycling conditions},
doi = {10.1590/1678-7757-2022-0306},
author = {Cifuentes Jiménez, Carolina Cecilia and Bolaños Carmona, María Victoria and Enrich Essvein, Tattiana and González López, Santiago and Álvarez Lloret, Pedro},
}