@misc{10481/81768,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81768},
abstract = {Pharmaceutical multicomponent solids have proved to efficiently modulate the physico-
chemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting
coformers for designing pharmaceutical cocrystals due to their wide safety profile and interesting
antioxidant properties. The novel 6-propyl-2-thiouracil multicomponent solids have been obtained
by mechanochemical synthesis and fully characterized by powder and single-crystal X-ray diffraction
methods. The analysis of supramolecular synthons has been further performed with computational
methods, with both results revealing a robust supramolecular organization influenced by the different
positions of the hydroxyl groups within the polyphenolic coformers. All novel 6-propyl-2-thiouracil
cocrystals show an enhanced solubility profile, but unfortunately, their thermodynamic stability in
aqueous media is limited to 24 h.},
organization = {FEDER-Universidad de Granada, Spain
	B-FQM-478-UGR20},
organization = {Spanish Government
	PID2020-115637GB-I00},
publisher = {MDPI},
keywords = {Propylthiouracil},
keywords = {Polyphenols},
keywords = {Cocrystals},
keywords = {Mechanochemistry},
keywords = {Crystal engineering},
title = {Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals},
doi = {10.3390/ph16030370},
author = {Acebedo Martínez, Francisco Javier and Verdugo Escamilla, Cristóbal and Domínguez Martín, Alicia and Gómez Morales, Jaime and Choquesillo Lazarte, Duane},
}