@misc{10481/81701,
year = {2023},
month = {3},
url = {https://hdl.handle.net/10481/81701},
abstract = {Genetic sensorineural hearing loss and Meniere disease have been associated with rare
variations in the coding and non-coding region of the human genome. Most of these variants were
classified as likely pathogenic or variants of unknown significance and require functional validation
in cellular or animal models. Given the difficulties to obtain human samples and the raising concerns
about animal experimentation, human-induced pluripotent stem cells emerged as cellular models
to investigate the interaction of genetic and environmental factors in the pathogenesis of inner ear
disorders. The generation of human sensory epithelia and neuron-like cells carrying the variants
of interest may facilitate a better understanding of their role during differentiation. These cellular
models will allow us to explore new strategies for restoring hearing and vestibular sensory epithelia
as well as neurons. This review summarized the use of human-induced pluripotent stem cells in
sensorineural hearing loss and Meniere disease and proposed some strategies for its application in
clinical practice},
organization = {Grant RH-0073-2021 from Andalusian Health Department. L.F.
has received funds from Sara Borrell’s postdoctoral Fellowship (ISCIII; grant code: CD20/00153).},
organization = {Postdoctoral grant from Economic Change, Industry, Knowledge and Universities Department (DOC_01677).},
organization = {Stem cell research from ibs.GRANADA (INTRAIBS-2021-07).},
publisher = {MDPI},
keywords = {Human-induced},
keywords = {Pluripotent stemcell},
keywords = {Inner ear disorders},
keywords = {Diseasemodeling},
keywords = {Sensorineural hearing loss},
keywords = {Meniere's Disease},
keywords = {Biomedical applications},
title = {Application of Human Stem Cells to Model Genetic Sensorineural Hearing Loss and Meniere Disease},
doi = {10.3390/cells12070988},
author = {Lamolda, Mar and Frejo, Lidia and Gallego Martínez, Álvaro and López Escámez, José Antonio},
}