@misc{10481/81599,
year = {2023},
month = {3},
url = {https://hdl.handle.net/10481/81599},
abstract = {Selenium (Se) has been defined as the “Janus element”, with one face showing antioxidant activity and the other pro-oxidant
activity. The biological effect of Se depends on both dose and speciation. Se nanoparticles are attracting major interest, although
their large-scale preparation for biomedical applications is not trivial. We hypothesize that acid anhydride-coated carbon dots (AACD)
are an attractive platform for preparing nanoparticles containing chemically defined Se. The reaction of AA-CD with 3-
selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups (CD-SeCN) that allow for
tuning the hydrosolubility. CD-SeCN has a Se content of 0.36 μmol per mg of nanoparticles, and they show the typical
photoluminescence of carbon dots. The selenocyanate groups (SeCN) exhibited glutathione peroxidase-like activity and
cytotoxicity. Data show that antioxidant behavior differs between normal and tumor cells, and the evaluation on HEK293 and
A549 cells reveals that the toxicity of CD-SeCN depends on dose, time, and intracellular glutathione (GSH) content. The toxicity
of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis, indicating
that CD-SeCN is neutralized. Additionally, high levels of intracellular GSH exert a protective effect. These results support a
pharmacological potential in cancers with low levels of intracellular GSH. The use of AA-CD as nanoplatforms is a general
strategy that paves the way for the engineering of advanced nanosystems},
organization = {Spanish institution
Ministerio de Ciencia, Innovacion y Universidades (No. CTQ2017-
86125-P)},
organization = {Unit of Excellence in Chemistry Applied to Biomedicine and the Environment},
organization = {Centro de Instrumentacion Cientifica (Universidad de Granada)},
organization = {Universidad de Granada/CBUA},
organization = {Springer Nature},
publisher = {Springer Nature},
keywords = {Selenium nanoparticles},
keywords = {Carbon dots},
keywords = {Glutathione peroxidase-like activity},
keywords = {Janus element},
keywords = {Nanomedicine},
title = {Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity},
doi = {10.1007/s12274-023-5442-3},
author = {Pérez Garrido, Laura and Ortega Muñoz, Mariano and Hernández Mateo, Fernando and López Jaramillo, Francisco Javier and Santoyo González, Francisco},
}