@misc{10481/81548,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81548},
abstract = {zation.
This study aims to evaluate bonding ability and both mechanical and chemical behavior of demineralized
dentin infiltrated with polymeric nanoparticles doped with dexamethasone (Dex-NPs).
Methods: Dentin conditioned surfaces were infiltrated with NPs, Dex-NPs or Dex-Zn-NPs. Bonded interfaces were
also created and stored for 24 h or 21d, and then submitted to microtensile bond strength testing. Dentin
remineralization was analyzed by Nanohardness, Young’s modulus and Raman analysis.
Results: At 21d of storage, dentin treated with undoped-NPs attained the lowest nanohardness and Young’s
modulus. Dex-NPs and Zn-Dex-NPs increased dentin nanohardness and Young’s modulus after 21d Raman
analysis showed high remineralization, crystallinity, crosslinking and better structure of collagen when functionalized
Dex-NPs were present at the dentin interface.
Conclusions: Infiltration of dentin with Dex-NPs promoted functional remineralization as proved by nanomechanical
and morpho-chemical evaluation tests. Dexamethasone in dentin facilitated crystallographic maturity,
crystallinity and improved maturity and secondary structure of dentin collagen.
Clinical significance: Using dexamethasone-functionalized NPs before resin infiltration is a clear option to obtain
dentin remineralization, as these NPs produce the reinforcement of the dentin structure, which will lead to the
improvement of the longevity of resin restorations},
organization = {Grant PID2020-114694RB-I00
funded by MCIN/AEI 10.13039/501100011033},
organization = {Funding for open access
charge: Universidad de Granada / CBUA.},
publisher = {Elsevier},
keywords = {Dentin},
keywords = {Dexamethasone},
keywords = {Nanoparticles},
keywords = {Raman},
keywords = {Remineralization},
title = {Dexamethasone-doped nanoparticles improve mineralization, crystallinity and collagen structure of human dentin},
doi = {10.1016/j.jdent.2023.104447},
author = {Toledano Pérez, Manuel and Osorio Ruiz, María Estrella and Aguilera, Fátima S.},
}