@misc{10481/81457,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/81457},
abstract = {Microbiota has a crucial role in the host blood pressure (BP) regulation. The present study analyzes whether the 
mineralocorticoid receptor antagonist spironolactone ameliorates the dysbiosic state in a genetic model of 
neurogenic hypertension. Twenty-week-old male Wistar Kyoto rats (WKY) and spontaneously hypertensive rats 
(SHR) were randomly allocated into three groups: untreated WKY, untreated SHR, and SHR treated with spi ronolactone for 5 weeks. Spironolactone restored the Firmicutes/Bacteroidetes proportion, and acetate producing bacteria populations to WKY levels. Spironolactone reduced the percentage of intestinal aerobic 
bacteria. The amelioration of gut dysbiosis was linked to a reduction in the gut pathology, an enhanced colonic 
integrity, a reduced gut permeability and an attenuated sympathetic drive in the gut. Spironolactone was unable 
to reduce neuroinflammation and oxidative stress in the paraventricular nuclei in the hypothalamus. Spi ronolactone reduced the higher Th17 cells proportion in mesenteric lymph nodes and Th17 infiltration in aorta, 
improved aortic endothelial function and reduced systolic BP. This study demonstrates for the first time that 
spironolactone reduces gut dysbiosis in SHR. This effect could be related to its capability to improve gut integrity 
and pathology due to reduced sympathetic drive in the gut.},
organization = {Comision Interministerial de Ciencia y Tecnologia, Ministerio de Economia y competitividad	PID2020-116347RB-I00},
organization = {Junta de Andalucia	CTS 164
P20_00193
A-CTS-318-UGR20},
organization = {European Commission},
organization = {Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spain},
organization = {European Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")},
publisher = {Elsevier},
keywords = {Spironolactone},
keywords = {Gut dysbiosis},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {SHR},
title = {Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by  reducing gut sympathetic tone in spontaneously hypertensive rats},
doi = {10.1016/j.biopha.2022.114149},
author = {González Correa, Cristina and Moleón Moya, Javier and Miñano, Sofía and Sánchez Santos, Manuel and Gómez Guzmán, Manuel and Jiménez Moleón, Rosario and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel},
}