@misc{10481/81395,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81395},
abstract = {Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.

Results: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.

Conclusion: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.},
organization = {Institut National du Cancer (INCA) France C864/A 14136},
organization = {Fondation ARC pour la Recherche sur le Cancer ARC 2019-DOC4},
organization = {IARC},
organization = {World Health Organization. International Agency for Research on Cancer (IARC)},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {NIHR Imperial Biomedical Research Centre (BRC)},
organization = {Danish Cancer Society},
organization = {Institut Gustave Roussy},
organization = {Mutuelle Generale de l'Education Nationale},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe. German Cancer Aid},
organization = {Helmholtz Association},
organization = {German Institute of Human Nutrition PotsdamRehbruecke (DIfE)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro},
organization = {Compagnia di San Paolo},
organization = {Dutch Ministry of Public Health, Welfare and Sports (VWS)},
organization = {Netherlands Cancer Registry (NKR)},
organization = {LK Research Funds},
organization = {Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland)},
organization = {World Cancer Research Fund International (WCRF)},
organization = {Netherlands Government},
organization = {Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII)},
organization = {Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)},
organization = {Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vaesterbotten (Sweden)},
organization = {Cancer Research UK  C8221/A29017  MR/N003284/1},
organization = {UK Research & Innovation (UKRI) Medical Research Council UK (MRC)  MC_UU_00006/1  MR/M012190/1
2016 - 184},
publisher = {Springer Nature},
keywords = {Fatty acids},
keywords = {Endometrial cancer},
keywords = {Epidemiology},
keywords = {Diet},
title = {Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition},
doi = {10.1186/s12885-023-10611-0},
author = {Yammine, S. G. and Sánchez Pérez, María José},
}