@misc{10481/81329,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81329},
abstract = {There is scarce evidence about early nutrition programming of dynamic aspects of glucose
homeostasis. We analyzed the long-term effects of early nutrition on glycemic variability in healthy
children. A total of 92 children participating in the COGNIS study were considered for this analysis,
who were fed with: a standard infant formula (SF, n = 32), an experimental formula (EF, n = 32),
supplemented with milk fat globule membrane (MFGM) components, long-chain polyunsaturated
fatty acids (LC-PUFAs), and synbiotics, or were breastfed (BF, n = 28). At 6 years old, BF children
had lower mean glucose levels and higher multiscale sample entropy (MSE) compared to those
fed with SF. No differences in MSE were found between EF and BF groups. Normal and slow
weight gain velocity during the first 6 months of life were associated with higher MSE at 6 years,
suggesting an early programming effect against later metabolic disorders, thus similarly to what we
observed in breastfed children. Conclusion: According to our results, BF and normal/slow weight
gain velocity during early life seem to protect against glucose homeostasis dysregulation at 6 years
old. EF shows functional similarities to BF regarding children’s glucose variability. The detection of
glucose dysregulation in healthy children would help to develop strategies to prevent the onset of
metabolic disorders in adulthood},
organization = {Randox Laboratories},
organization = {Contract University of Granada General Foundation},
organization = {SMARTFOODS (CIEN) Contract University of Granada General Foundation},
organization = {Spanish Government},
organization = {HORIZON 2020 EU DynaHEALTH Project	633595},
organization = {Junta de Andalucia Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades	404},
organization = {Fundacion Carolina, Madrid, Spain},
publisher = {MDPI},
keywords = {Early nutrition},
keywords = {Growth velocity},
keywords = {Continuous glucose monitoring},
keywords = {Multiscale sample entropy},
keywords = {Glucose coefficient of variation},
keywords = {Glucose homeostasis; glycemic variability},
keywords = {Body fat mass},
title = {Long-Term Effects and Potential Impact of Early Nutrition with Breast Milk or Infant Formula on Glucose Homeostasis Control in Healthy Children at 6 Years Old: A Follow-Up from the COGNIS Study},
doi = {10.3390/nu15040852},
author = {Diéguez Castillo, Estefanía and Nieto Ruiz, Ana María and Herrmann, Florian and Agil Abdalla, Mhmad Ahmad and Azaryah, Hatim and García Santos, José Antonio and García Bermúdez, María Mercedes and Campoy Folgoso, Cristina},
}