@misc{10481/81323,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81323},
abstract = {Non-alcoholic fatty liver disease (NAFLD) seems to have some molecular links with
atherosclerosis (ATH); however, the molecular pathways which connect both pathologies remain un explored to date. The identification of common factors is of great interest to explore some therapeutic
strategies to improve the outcomes for those affected patients. Differentially expressed genes (DEGs)
for NAFLD and ATH were extracted from the GSE89632 and GSE100927 datasets, and common
up- and downregulated DEGs were identified. Subsequently, a protein–protein interaction (PPI)
network based on the common DEGs was performed. Functional modules were identified, and the
hub genes were extracted. Then, a Gene Ontology (GO) and pathway analysis of common DEGs
was performed. DEGs analysis in NAFLD and ATH showed 21 genes that were regulated similarly
in both pathologies. The common DEGs with high centrality scores were ADAMTS1 and CEBPA
which appeared to be down- and up-regulated in both disorders, respectively. For the analysis of
functional modules, two modules were identified. The first one was oriented to post-translational
protein modification, where ADAMTS1 and ADAMTS4 were identified, and the second one mainly
related to the immune response, where CSF3 was identified. These factors could be key proteins with
an important role in the NAFLD/ATH axis.},
organization = {Instituto de Salud Carlos III, grant PI18-00803},
organization = {European Regional Development Fund (FEDER) and by Junta de Andalucía, grant
PI-0268-2019. M.F.-M},
organization = {Operational Programme for Youth Employment of the Junta de
Andalucía under ref: POEJ_04/2022-12. CG-F},
organization = {postdoctoral Sara Borrell fellowship from
the Instituto de Salud Carlos III, with co-funding by FEDER (CD20/00022)},
organization = {B.R.-G. and S.G.S. are
funded by postdoctoral and predoctoral fellowships (RH-0069-2021 and FI19/00118) from Junta de
Andalucía and Instituto de Salud Carlos III, respectively},
publisher = {MDPI},
keywords = {Atherosclerosis},
keywords = {Non-alcoholic fatty liver disease},
keywords = {Protein-protein interaction networks},
title = {Analysis of the Genetic Relationship between Atherosclerosis and Non-Alcoholic Fatty Liver Disease through Biological Interaction Networks},
doi = {10.3390/ijms24044124},
author = {Andujar Vera, Francisco and Ferrer Millán, Maria and García Fontana, Cristina and García Fontana, Beatriz and González Salvatierra, Sheila and Sanabria de la Torre, Raquel and Martínez Heredia, Luis and Riquelme Gallego, Blanca and Muñoz Torres, Manuel Eduardo},
}