@misc{10481/81042,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81042},
abstract = {The acid treatment of 6,7-seco-abietane dialdehydes gives, in high yield, the corresponding derivatives with the 4a-methyltetrahydrofluorene skeleton of taiwaniaquinoids. A mechanism involving the elimination of formic acid from the cyclic aldol intermediate is proposed here. This process can be postulated as a new biogenetic pathway from abietane diterpenes to taiwaniaquinoids. Using this novel reaction, the first enantiospecific synthesis of bioactive natural cupresol and taxodal has been obtained.},
organization = {Regional Government of Andalusia (Project
B-FQM-278-UGR20)},
organization = {Assistance was provided to the group FQM-348},
publisher = {MDPI},
keywords = {Bioactive natural products},
keywords = {Synthesis},
keywords = {Diterpenoids},
keywords = {Taiwaniaquinoids},
title = {Unprecedented Elimination Reactions of Cyclic Aldols: A New Biosynthetic Pathway toward the Taiwaniaquinoid Skeleton},
doi = {10.3390/molecules28041524},
author = {Guardia Monteagudo, Juan José and Fernández Vargas, Antonio and Justicia Ladrón De Guevara, José and Zentar, Houda and Álvarez-Manzaneda, Ramón and Álvarez De Manzaneda Roldán, Enrique and Chahboun Karimi, Rachid},
}