@misc{10481/80938,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80938},
abstract = {Introduction: Although often overlooked in clinical settings, accumulation of persistent organic pollutants (POPs)
in visceral adipose tissue (VAT) is thought to be a relevant risk factor for metabolic syndrome (MetS).
Methods: One hundred and seventeen patients undergoing non-oncological surgery were randomly recruited and
classified as MetS + if presented 3 out of the 5 MetS components: waist circumference (WC), systolic and diastolic
blood pressure (SBP and DBP, respectively), serum glucose, insulin, triglycerides (TG) and high-density
lipoprotein (HDL) cholesterol levels, according International Diabetes Federation (IDF) criteria. Seventeen
organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were measured in adipose tissue samples.
Linear, logistic and weighted quantile sum (WQS) regression models, adjusted for age and sex, were
performed.
Results: One third of the participants were males (36.8%) with a median age of 44 years, showing clinical evidences
of MetS (35.0%). Adjusted linear regression models showed that WC correlated positively with all OCP
concentrations. Higher fasting serum glucose levels were related to higher HCB and γ-HCH concentrations. The remaining OCPs and PCBs were not associated with this MetS component. HCB was inversely associated with
HDL cholesterol levels, while PCB-180 was positively associated. HCB and γ-HCH concentrations were also
positively correlated with DBP and SBP levels. PCB-138 was also positively associated with SBP. Adjusted logistic
models revealed that exposure to HCB and γ-HCH were associated with increased odds of MetS [ORs (95%CI)
1.53 (1.22–1.92) and 1.39 (1.10–1.76) respectively; p < 0.01]. No associations were observed for the remaining
POPs. WQS models showed a positive and significant mixture effect of POPs on the odds of MetS (exp [beta] =
2.34; p < 0.001), with γ-HCH (52.9%), o,p’-DDT (26.9%) and HCB (19.7%) driving the association.
Conclusions: Our findings support that POPs accumulated in VAT, specifically HCB and (gamma)-HCH, are
associated with both isolated components and clinically diagnosed SMT.},
organization = {HBM4EU under Grant Agreement
#733032},
organization = {Biomedical Research Networking Center-CIBER de
Epidemiología y Salud Pública (CIBERESP) of the Institute of Health
Carlos III},
organization = {Institute of Health Carlos
III—supported by the European Regional Development Fund/FEDER
(FIS-PI16/01820, FIS-PI16/01812 and FIS-PI16/01858)},
organization = {Junta de Andalucía-Consejería de Salud (PS-0506-2016)},
organization = {Ramon y Cajal Program (RYC-2016-20155,
Ministerio de Economía, Industria y Competitividad, Spain)},
organization = {(FPU17/01848)},
publisher = {Elsevier},
keywords = {Adipose tissue},
keywords = {Metabolic syndrome (MetS)},
keywords = {Endocrine disruptors},
keywords = {Persistent organic pollutants (POPs)},
keywords = {Hexachlorobenzene (HCB)},
keywords = {Hexachlorohexane (HCH)},
title = {Cross-sectional associations of persistent organic pollutants measured in adipose tissue and metabolic syndrome in clinically diagnosed middle-aged adults},
doi = {10.1016/j.envres.2023.115350},
author = {Reina Pérez, Iris and Artacho Cordón, Francisco and Mustieles Miralles, Vicente and Jiménez Díaz, Inmaculada and Iribarne Durán, Luz María and Arrebola Moreno, Juan Pedro and Olea Serrano, Nicolás and Fernández Cabrera, Mariana Fátima},
}