@misc{10481/80921,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/80921},
abstract = {Hematological malignancies are a highly heterogeneous group of diseases with varied molecular and phenotypical
characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complexes play significant
roles in the regulation of gene expression, being essential for processes such as cell maintenance and differentiation
in hematopoietic stem cells. Furthermore, alterations in SWI/SNF complex subunits, especially in ARID1A/1B/2,
SMARCA2/4, and BCL7A, are highly recurrent across a wide variety of lymphoid and myeloid malignancies. Most
genetic alterations cause a loss of function of the subunit, suggesting a tumor suppressor role. However, SWI/SNF
subunits can also be required for tumor maintenance or even play an oncogenic role in certain disease contexts. The
recurrent alterations of SWI/SNF subunits highlight not only the biological relevance of SWI/SNF complexes in hematological
malignancies but also their clinical potential. In particular, increasing evidence has shown that mutations
in SWI/SNF complex subunits confer resistance to several antineoplastic agents routinely used for the treatment of
hematological malignancies. Furthermore, mutations in SWI/SNF subunits often create synthetic lethality relationships
with other SWI/SNF or non-SWI/SNF proteins that could be exploited therapeutically. In conclusion, SWI/SNF complexes
are recurrently altered in hematological malignancies and some SWI/SNF subunits may be essential for tumor
maintenance. These alterations, as well as their synthetic lethal relationships with SWI/SNF and non-SWI/SNF proteins,
may be pharmacologically exploited for the treatment of diverse hematological cancers.},
organization = {Aula de Investigacion sobre la Leucemia infantil: Heroes contra la Leucemia},
organization = {Ministry of Science and Innovation, Spain (MICINN)
Spanish Government	PID2021-126111OB-I00},
organization = {Junta de Andalucia	PIGE-0440-2019
PI-0135-2020
P20_00688},
organization = {University of Granada	B-CTS-480-UGR20
OTRI-UGR	P32_2020_001},
organization = {Spanish Association Against Cancer	LAB-AECC-2018
Spanish Government	FPU17/00067},
organization = {University of Granada},
organization = {Programa Operativo de Empleo Juvenil y de la Iniciativa de Empleo Juvenil 2021-2023	8114},
organization = {Scientific Foundation of the Spanish Association Against Cancer in Granada	PRDGR21428SANJ},
organization = {"Fundacion Benefica Anticancer Santa Candida y San Francisco Javier" predoctoral fellowship},
organization = {"UGR Plan Propio" contract - Spanish Ministry of Universities},
organization = {European Union Next Generation		
FPU17/01258},
publisher = {BMC},
keywords = {SWI/SNF},
keywords = {BAF complexes},
keywords = {Chromatin remodeling},
keywords = {Epigenetics},
keywords = {Lymphoma},
keywords = {Leukemia},
keywords = {Multiple myeloma},
keywords = {Synthetic lethality},
keywords = {Drug resistance},
title = {SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities},
doi = {10.1186/s12943-023-01736-8},
author = {Andrades Delgado, Álvaro and Peinado Fernández, Paola and Álvarez Pérez, Juan Carlos and Sanjuan Hidalgo, Juan and García García, Daniel Jesús and Arenas Molina, Alberto Manuel and Matia González, Ana María and Medina Vico, Pedro Pablo},
}