@misc{10481/80805,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/80805},
abstract = {There is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing
risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the
prevention and reduction of the progression of AD. Honey, a good source of antioxidants and
bioactive molecules, has been tied to many health benefits, including those from neurological origin.
Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are
still unknown. The aim of this study is to further its characterization, focusing on the phenolic
profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep
analysis on the pathophysiological features of AD such as oxidative stress, amyloid-  aggregation,
and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans.
AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the
dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally,
AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD
prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although
the real contribution of AH remains unclear. The mechanisms under the observed effects might be
attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results
increase the interest to study the biomedical applications of AH; however, more research is needed to
deepen the mechanisms under the observed effects.},
organization = {FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento	B-AGR-193-UGR18},
publisher = {MDPI},
keywords = {A-beta},
keywords = {Tau},
keywords = {AAPH},
keywords = {Oxidative stress},
keywords = {ROS},
keywords = {Phytochemical},
keywords = {Alzheimer},
keywords = {Tauopathies},
title = {In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain},
doi = {10.3390/antiox12020404},
author = {Romero Márquez, José Manuel and Navarro Hortal, María Dolores and Esteban Muñoz, Adelaida and Sánchez González, Cristina and Rivas García, Lorenzo and Quiles Morales, José Luis and Forbes Hernández, Tamara Yuliett},
}