@misc{10481/80746,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80746},
abstract = {Neurodegenerative diseases are known for their wide range of harmful conditions related
to progressive cell damage, nervous system connections and neuronal death. These pathologies
promote the loss of essential motor and cognitive functions, such as mobility, learning and sensation.
Neurodegeneration affects millions of people worldwide, and no integral cure has been created
yet. Here, bioactive compounds have been proven to exert numerous beneficial effects due to their
remarkable bioactivity, so they could be considered as great options for the development of new
neuroprotective strategies. Phenolic bioactives have been reported to be found in edible part of
plants; however, over the last years, a large amount of research has focused on the phenolic richness
that plant by-products possess, which sometimes even exceeds the content in the pulp. Thus, their
possible application as an emergent neuroprotective technique could also be considered as an optimal
strategy to revalorize these agricultural residues (those originated from plant processing). This review
aims to summarize main triggers of neurodegeneration, revise the state of the art in plant extracts
and their role in avoiding neurodegeneration and discuss how their main phenolic compounds could
exert their neuroprotective effects. For this purpose, a diverse search of studies has been conducted,
gathering a large number of papers where by-products were used as strong sources of phenolic
compounds for their neuroprotective properties. Finally, although a lack of investigation is quite
remarkable and greatly limits the use of these compounds, phenolics remain attractive for research
into new multifactorial anti-neurodegenerative nutraceuticals.},
organization = {Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia	P18-TP-3589},
organization = {MCIN/NextGenerationEU	TED2021-132043B-I00},
organization = {University of Granada	P18-TP-3589},
organization = {Spanish Government	FPU21/02714
MCIN/AEI	RYC2021-032119-I
AGR274
265},
publisher = {MDPI},
keywords = {Neurodegeneration},
keywords = {Plant by-products},
keywords = {Phenolic compounds},
keywords = {Neuroprotection},
keywords = {Oxidative stress},
keywords = {Protein aggregation},
keywords = {Neuroinflammation},
keywords = {Mitochondrial dysfunction},
keywords = {AChE},
title = {Neuroprotective Effects of Agri-Food By-Products Rich in Phenolic Compounds},
doi = {10.3390/nu15020449},
author = {Rojas García, Alejandro and Fernández Ochoa, Álvaro and Cádiz Gurrea, María de la Luz and Arráez Román, David and Segura Carretero, Antonio},
}