@misc{10481/80633,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/80633},
abstract = {Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge
of its pathogenesis has made it possible to advance the development of different therapeutic strategies.
However, the appearance of drug resistance constitutes one of the main causes of treatment
failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve
antitumor treatment, due to their ability to regulate the pathways involved in the development of
carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro
and in vivo studies of these substances in combination with cytotoxic drugs have shown that they
reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize
the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing
capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. These
compounds may hold a promising future in improving the treatment of colorectal cancer.},
organization = {P20_00540 (Proyectos I+D+i Junta de
Andalucía 2020)},
organization = {PYC20 RE 035 and P18-TP-1420 (Junta de Andalucía)},
organization = {PI19/01478 (Instituto de
Salud Carlos III, Innbio INB-009 (Granada University and ibs. GRANADA)},
organization = {RTC2019-006870-1
(Spanish Minsistry of Science, Innovation and Universities)},
organization = {FPU (2019
and 2020) grant from Ministerio de Educación, Ciencia y Deporte y Competitividad (Spain)},
publisher = {MDPI},
keywords = {Colorectal cancer},
keywords = {Vegetables},
keywords = {Multidrug resistance},
keywords = {Biomolecules},
keywords = {Resistance mechanisms},
title = {Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer},
doi = {10.3390/app13042667},
author = {Quiñonero Muñoz, Francisco José and Mesas Hernández, Cristina and Peña Contreras, María Mercedes and Cabeza Montilla, Laura and Perazzoli, Gloria and Melguizo Alonso, Consolación and Ortiz Quesada, Raúl and Prados Salazar, José Carlos},
}