@misc{10481/80469,
year = {2021},
month = {6},
url = {https://hdl.handle.net/10481/80469},
abstract = {We aimed to assess the relationships among the
adipose tissue’s (AT) oxidative microenvironment, in situ
accumulated persistent organic pollutant (POP) concentrations,
and cancer development. POP and oxidative stress levels were
quantified in AT samples from 382 adults recruited within the
GraMo cohort (2003−2004) in Granada (Spain). The 16-year
cancer incidence was ascertained by reviewing health/administrative
databases. Cox-regression models and mediation analyses
were performed. The enzymes superoxide dismutase (SOD) and
glutathione reductase (GRd) were positively associated with the
risk of non-hormone-dependent (NHD) cancer [adjusted hazard
ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR
2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for
covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70;
95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD
cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a
potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated =
33 and 47%, respectively). Our results highlight the relevance of human AT’s oxidative microenvironment as a predictor of future
cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be
interpreted with caution and confirmed in future studies.},
organization = {Ramon y Cajal Program (Ministerio de Economia, Industria y Competitividad, Spain)	RYC-2016-20155},
organization = {Instituto de Salud Carlos III	FI17/00310},
organization = {Junta de Andalucia},
organization = {European Commission		
PI16/01858
BA15/00093
EF-0428-2016
PI20/01568
Human Biomonitoring for Europe Project (European Union Commission H2020-EJP-HBM4EU},
publisher = {American Chemical Society},
keywords = {Oxidative stress},
keywords = {Persistent organic pollutants},
keywords = {Organochlorine pesticides},
keywords = {Polychlorinated biphenyls},
keywords = {Cancer},
title = {Adipose tissue redox microenvironment as a potential link between persistent organic pollutants and the 16-year incidence of non-hormone dependent cancer},
doi = {10.1021/acs.est.0c08180},
author = {Mustieles Miralles, Vicente and Pérez Carrascosa, Francisco Miguel and León, Josefa and Gómez Peña, Celia and Artacho Cordón, Francisco and Barrios Rodríguez, Rocío and Olmedo Requena, María Rocío and Expósito Hernández, José and Jiménez Moleón, José Juan and Arrebola Moreno, Juan Pedro},
}