@misc{10481/80411,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80411},
abstract = {In general, the risk of being diagnosed with cancer increases with age; however, the
development of estrogen-receptor-positive (ER+) cancer types in women are more closely related
to menopausal status than age. In fact, the general risk factors for cancer development, such as
obesity-induced inflammation, show differences in their association with ER+ cancer risk in pre- and
postmenopausal women. Here, we tested the role of the principal estrogens in the bloodstream before
and after menopause, estradiol (E2) and estrone (E1), respectively, on inflammation, epithelial-tomesenchymal
transition (EMT) and cancer stem cell enrichment in the human ER+ cervical cancer cell
line HeLa. Our results demonstrate that E1, contrary to E2, is pro-inflammatory, increases embryonic
stem-transcription factors (ES-TFs) expression and induces EMT in ER+ HeLa cells. Moreover, we
observed that high intratumoural expression levels of 17 -Hydroxysteroid dehydrogenase (HSD17B)
isoforms involved in E1 synthesis is a poor prognosis factor, while overexpression of E2-synthetizing
HSD17B isoforms is associated with a better outcome, for patients diagnosed with ER+ ovarian and
uterine corpus carcinomas. This work demonstrates that E1 and E2 have different biological functions
in ER+ gynaecologic cancers. These results open a new line of research in the study of ER+ cancer
subtypes, highlighting the potential key oncogenic role of E1 and HSD17B E1-synthesizing enzymes
in the development and progression of these diseases.},
organization = {Instituto de Salud Carlos III	PIE16-00045},
organization = {Ministry of Health and Family of the Junta de Andalucia},
organization = {European Commission	PEMP-0205-2020},
organization = {Spanish Ministry of Science, Innovation and Universities (MICIN)	MSCA-IF-2018 845104},
organization = {European Commission
European Commission Joint Research Centre	PID2020-119502RJ-I00},
organization = {State Research Agency from the Spanish Ministry of Science and Innovation (MICIN/AEI)	CMC-CTS963
0006/2018},
organization = {Chair "Doctors Galera-Requena in cancer stem cell research"	PECART-0027-2020
regional Ministry of Health},
organization = {Consejeria de Salud y Familias		
RTI2018-101309-B-C22
RYC2020-030808-I},
publisher = {MDPI},
keywords = {ER+ cancer},
keywords = {Estradiol},
keywords = {Estrone},
keywords = {Inflammation},
keywords = {NF-KB},
keywords = {HSD17B},
title = {Estradiol and Estrone Have Different Biological Functions to Induce NF-kappa B-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells},
doi = {10.3390/ijms24021221},
author = {Díaz Ruano, Ana Belén and Martínez Alarcón, Nuria and Perán, Macarena and Benabdellah, Karim and García Martínez, María de los Ángeles and Preda, Ovidiu and Ramírez Tortosa, César Luis and González hernández, Andrea and Marchal Corrales, Juan Antonio and Picón Ruiz, Manuel},
}