@misc{10481/80330,
year = {2022},
month = {5},
url = {https://hdl.handle.net/10481/80330},
abstract = {Background: Gestational diabetes (GD) and maternal excess weight are common pregnancy conditions
that increase the risk of future complications for both the mother and her offspring. Their consequences
on neurodevelopment are widely described in the literature, but less is known concerning the potential
transgenerational influence on the brain structure.
Methods: We used a combination of support vectors machine and hierarchical clustering to investigate
the potential presence of anatomical brain differences in a sample of 109 children aged six years, born to
mothers with overweight or obesity, or to mothers diagnosed with GD during pregnancy.
Results: Significant effects are visible in the brain of children born to mothers with GD associated with
pregestational excess weight, especially overweight instead of obesity. No differences in children's brain
were observed when considering those born to normal-weight mothers.
Conclusions: Our study highlights the need for clinical attention of pregnant women at risk to develop
GD, and especially those with pregestational excess weight, since this status was found to be associated
with detectable transgenerational brain changes. These effects may be due to the absence of specific and
individualized intervention in these mothers during pregnancy.},
organization = {Spanish Ministry of Innovation and
Science. Junta de Andalucía: Excellence Projects (P06-CTS-02341)},
organization = {Spanish
Ministry of Economy and Competitiveness (BFU2012-40254-C03-01)},
organization = {DynaHEALTH EU Project - HORIZON 2020 Research and
Innovation Programme, Grant Agreement No 633595},
organization = {Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396)},
publisher = {Elsevier},
keywords = {Body mass index},
keywords = {Brain structure},
keywords = {Gestational diabetes},
keywords = {Transgenerational effects},
title = {Influence of Gestational Diabetes and Pregestational Maternal BMI on the Brain of Six-Year-Old Offspring},
doi = {10.1016/j.pediatrneurol.2022.05.005},
author = {Manuello, Jordi and Verdejo Román, Juan and Torres Espínola, Francisco and Escudero Marín, Mireia and Catena Martínez, Andrés and Campoy Folgoso, Cristina},
}