@misc{10481/80034,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/80034},
abstract = {The high recurrence rate of common denture stomatitis after antifungal treatment is still concerning. This
condition is caused by low patient compliance and incomplete local elimination of the main etiological factor —
Candida albicans, often associated with other microorganisms, such as Streptococcus species. Impregnating denture
materials with antimicrobials for local delivery is a strategy that can overcome the side effects and improve
the efficacy of conventional treatments (topical and/or systemic). In this work, we describe the development of
three hard autopolymerizing reline acrylic resins (Kooliner, Ufi Gel Hard, and Probase Cold) loaded with
different percentages of chlorhexidine (CHX). The novel formulations were characterized based on their antimicrobial
activity, mechanical, morphological and surface properties, in-vitro drug release profiles, and cytotoxicity.
The addition of CHX in all resins did not change their chemical and mechanical structure. Among all the
tested formulations, Probase Cold loaded with 5 wt% CHX showed the most promising results in terms of
antimicrobial activity and lack of serious detrimental mechanical, morphological, surface, and biological
properties.},
organization = {Fundação para a Ciência e Tecnologia (FCT), Portugal},
organization = {Centro 2020 through the following projects: UIDB/04138/2020 and UIDP/04138/2020 (iMed.ULisboa), UIDB/05608/2020 and UIDP/05608/2020 (H&TRC), UIDP/04044/2020, PAMI - ROTEIRO/0328/2013 (N° 022158)},
organization = {MATIS (CENTRO-01-0145-FEDER-000014 - 3362)},
organization = {Grant (CEECIND/03143/2017)},
publisher = {Elsevier},
keywords = {Antimicrobial},
keywords = {Polymeric resins},
keywords = {Drug delivery system},
keywords = {Denture stomatitis},
title = {Development of a chlorhexidine delivery system based on dental reline acrylic resins},
doi = {10.1016/j.ijpharm.2022.122470},
author = {Bettencourt, Ana F. and Arias Moliz, María Teresa},
}