@misc{10481/79281,
year = {2022},
month = {10},
url = {https://hdl.handle.net/10481/79281},
abstract = {Cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (ML) show clinical spectra
that can range from a localized lesion (with a spontaneous healing process) to cases that progress
to a generalized systemic disease with a risk of death. The treatment of leishmaniasis is complex
since most of the available drugs show high toxicity. The development of an effective topical drug
formulation for CL and ML treatment offers advantages as it will improve patient’s compliance to the
therapy given the possibility for self-administration, as well as overcoming the first pass metabolism
and the high costs of currently available alternatives. The most common dosage forms include solid
formulations, such as membranes and semi-solid formulations (e.g., ointments, creams, gels, and
pastes). Topical treatment has been used as a new route of administration for conventional drugs
against leishmaniasis and its combinations, as well as to exploit new substances. In this review, we
discuss the advantages and limitations of using topical drug delivery for the treatment of these two
forms of leishmaniasis and the relevance of combining this approach with other pharmaceutical
dosage forms. Emphasis will also be given to the use of nanomaterials for site-specific delivery.},
organization = {Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)},
organization = {Fundacao de Amparo a Pesquisa do Estado do Sergipe (FAPITEC)	88887.159533/2017-00},
organization = {Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)	CNPq 301964/2019-0	
01/2019	
06/2019},
organization = {Fundacao Carolina},
publisher = {MDPI},
keywords = {Cutaneous leishmaniasis (CL)},
keywords = {Mucocutaneous leishmaniasis (ML)},
keywords = {Topical formulations},
keywords = {Drug delivery},
keywords = {Nanomaterials},
title = {Cutaneous/Mucocutaneous Leishmaniasis Treatment for Wound Healing: Classical versus New Treatment Approaches},
doi = {10.3390/microbiolres13040059},
author = {Severino, Patricia and Clares Naveros, Beatriz},
}