@misc{10481/79192,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/79192},
abstract = {Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.},
organization = {Instituto De Salud Carlos III (European Regional Development Fund, ERDF, a way to build Europe)		
European Commission	PI18/00191},
organization = {World Health Organization	2005328},
organization = {Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London},
organization = {Danish Cancer Society},
organization = {Ligue Contre le Cancer (France)		
Institut Gustave Roussy (France)		
Mutuelle Generale de l'Education Nationale (France)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Deutsche Krebshilfe		
German Cancer Research Center (DKFZ) (Germany)		
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {Fondazione AIRC per la ricerca sul cancro		
Compagnia di San Paolo		
Consiglio Nazionale delle Ricerche (CNR)},
organization = {Netherlands Government		
Netherlands Government
World Cancer Research Fund International (WCRF)},
organization = {Netherlands Government},
organization = {Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) (Spain)},
organization = {Junta de Andalucia		
Principality of Asturias		
Regional Government of Basque Country (Spain)		
Regional Government of Murcia (Spain)		
Regional Government of Navarra (Spain)		
Catalan Institute of Oncology-ICO (Spain)},
organization = {Swedish Cancer Society		
Swedish Research Council		
County Council of Skane (Sweden)		
County Council of Vaesterbotten (Sweden)},
organization = {Cancer Research UK		
UK Research & Innovation (UKRI)
Medical Research Council UK (MRC)	14136	
C8221/A29017	
1000143	
MR/M012190/1},
organization = {NIHR Cambridge Biomedical Research Centre diet, nutrition and lifestyle theme	MC_UU_0006/3},
organization = {Consejo Nacional de Ciencia y Tecnologia (CONACyT)	IS-BRC-1215-20014},
organization = {Instituto de Salud Carlos III (European Social Fund (ESF) investing in your future)	693636	
FI19/00185	
CD20/00071	
CPII20/00009},
publisher = {MDPI},
keywords = {Polyphenol},
keywords = {Intake},
keywords = {Body weight},
keywords = {Obesity},
keywords = {Cohort},
keywords = {EPIC},
title = {Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort},
doi = {10.3390/antiox11122425},
author = {Gil Lespinard, Mercedes and Molina Montes, María Ester},
}