@misc{10481/79095,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/79095},
abstract = {Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions
consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation
of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries
to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing
mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize
the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial
culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the
dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus
casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly
after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the costeffective
prevention of secondary caries.},
organization = {Spanish Government},
organization = {European Commission},
organization = {Rey Juan Carlos University	CTQ2017-88642-R	
PID2021-125216OB-I00	
2022/00004/010},
publisher = {BMC},
keywords = {Dental caries},
keywords = {Dental adhesive},
keywords = {Drug delivery system},
keywords = {Mesoporous silica nanoparticles},
keywords = {L-arginine},
title = {L‑arginine‑containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria},
doi = {10.1186/s12951-022-01714-0},
author = {López Ruiz, Marta and Ferrer Luque, Carmen María and Ruiz Linares, Matilde},
}